AI Article Synopsis
- CD23 acts as a key player in allergic responses and diseases like rheumatoid arthritis, influencing how the immune system reacts.
- Researchers identified ADAM10 as the main enzyme responsible for releasing CD23 from cells, using various experimental techniques and animal models.
- Targeting ADAM10 may offer new treatment options for allergic reactions and related diseases, paving the way for future research on its broader role.
Article Abstract
CD23, the low-affinity immunoglobulin E receptor, is an important modulator of the allergic response and of diseases such as rheumatoid arthritis. The proteolytic release of CD23 from cells is considered a key event in the allergic response. Here we used loss-of-function and gain-of-function experiments with cells lacking or overexpressing candidate CD23-releasing enzymes (ADAM8, ADAM9, ADAM10, ADAM12, ADAM15, ADAM17, ADAM19 and ADAM33), ADAM-knockout mice and a selective inhibitor to identify ADAM10 as the main CD23-releasing enzyme in vivo. Our findings provide a likely target for the treatment of allergic reactions and set the stage for further studies of the involvement of ADAM10 in CD23-dependent pathologies.
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