Lead (Pb) sorption onto oxide surfaces in soils may strongly influence the risk posed from incidental ingestion of Pb-contaminated soil. Lead was sorbed to model oxide minerals of corundum (alpha-Al(2)O(3)) and ferrihydrite (Fe(5)HO(8).4H(2)O). The Pb-sorbed minerals were placed in a simulated gastrointestinal tract (in vitro) to simulate ingestion of Pb-contaminated soil. The changes in Pb speciation were determined using extended X-ray absorption fine structure (EXAFS) and X-ray absorption near edge spectroscopy (XANES). Both corundum (sorption maximum of 2.13 g kg(-1)) and ferrihydrite (sorption maximum of 38.6 g kg(-1)) have been shown to sorb Pb, with ferrihydrite having a very high affinity for Pb. The gastric bioaccessible Pb for corundum was >85% for corundum when the concentration of Pb was >200 mg kg(-1). Bioaccessible Pb was not detectable at =200 mg kg(-1). Bioaccessible Pb ranged from 53 to 88% for ferrihydrite. The bioaccessible Pb was below detection limits for the intestinal phase in the ferrihydrite system. Solid phase speciation identified both inner- (mononuclear bidentate) and outer-sphere species for Pb sorbed to corundum, while only an inner-sphere (mononuclear bidentate) complex was found for ferrihydrite. Although corundum and ferrihydrite can bind Pb, they fail to significantly reduce gastric bioaccessible Pb but do reduce intestinal bioaccessible Pb. Treatment of Pb-contaminated soil with corundum or ferrihydrite may reduce Pb solubility under field soil conditions of pH > 4. However, much of the sorbed Pb will become bioaccessible under gastric conditions (pH 1.5-2.5) if this soil is ingested. Caution should be used before using these materials to remediate a soil where soil ingestion is an important exposure pathway.
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http://dx.doi.org/10.2134/jeq2005.0467 | DOI Listing |
J Sci Food Agric
January 2025
Institute of Drug Discovery Technology, Ningbo University, Ningbo, China.
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January 2025
Department of Pharmaceutical Sciences and Pharmaceutics, Faculty of Pharmacy, Applied Science Private University, Amman, 11937, Jordan.
Introduction: The beneficial effects of probiotics are encountered by their low viability in gastrointestinal conditions and their insufficient stability during manufacturing, throughut the gastrointestinal transit, and storage. Therefore, novel systems are highly required to improve probiotics delivery.
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Int J Biol Macromol
January 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:
Probiotics have brought many health benefits to the human body. However, their viability during gastrointestinal transit is a concern. Therefore, this study selected Mesona chinensis polysaccharide (MCP), an edible natural polysaccharide, and constructed a new type of microcapsules using MCP as raw material to prepare cross-linked calcium ions through a microfluidic system as an ideal intestinal targeting carrier to achieve precise delivery of bioactive substances.
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Xiamen Medical College, Xiamen, Fujian 361023, China. Electronic address:
This study analyzed dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides from Tartary buckwheat (Fagopyrum tataricum) protein hydrolysates, known for managing chronic diseases. Simulated gastrointestinal digestion enhanced the inhibitory activity of DPP-IV. Using anion-exchange resin DEAE-52, reverse high-performance liquid chromatography, and LC-MS/MS, eight novel peptides were identified.
View Article and Find Full Text PDFSci Rep
January 2025
Key Laboratory for Stem Cells and Tissue Engineering Ministry of Education, Guangdong Provincial Key Laboratory of Brain Function and Disease, Institute of Spinal Cord Injury, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Neuromuscular diseases usually manifest as abnormalities involving motor neurons, neuromuscular junctions, and skeletal muscle (SkM) in postnatal stage. Present in vitro models of neuromuscular interactions require a long time and lack neuroglia involvement. Our study aimed to construct rodent bioengineered spinal cord neural network-skeletal muscle (NN-SkM) assembloids to elucidate the interactions between spinal cord neural stem cells (SC-NSCs) and SkM cells and their biological effects on the development and maturation of postnatal spinal cord motor neural circuits.
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