Background: Influenza is an important public health problem that particularly affects elderly subjects and influenza vaccination is a safe, effective and efficient method for prevention of influenza-related complications in elderly individuals with or without underlying chronic conditions. This study aims to analyze adjusted time trends in the coverage of influenza vaccination among elderly Spanish subjects and to identify which variables were associated with the probability of having been vaccinated in 2003.
Methods: We undertook a cross-sectional study using data of individuals aged >/=65 years drawn from the 1993, 1995, 1997, 2001, and 2003 Spanish National Health Surveys. The answer to the question 'Did you have a 'flu shot in the latest campaign' was used as the dependent variable, and socio-demographic and health-related characteristics were analyzed as independent variables. Coverage of vaccination for each year was adjusted by the direct method for both age and gender. Multivariate logistic regression was used to estimate the independent effect of variables on the receipt of influenza vaccine.
Results: 15 989 records were analyzed. Adjusted influenza coverage increased from 50.1% in 1993 to 63.7% in 2003 (P < 0.001). The variables that were significantly associated with a higher likelihood of being vaccinated were older age, suffering a chronic disease, residence in towns with <10 000 inhabitants, 'worse' self-perceived health and non-smokers.
Conclusions: Coverage among the Spanish elderly has increased significantly from 1993 to 2003. Still, there is room for improvement, particularly, among the subjects with 'good' self-perceived health, those with no concomitant medical conditions, and smokers.
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http://dx.doi.org/10.1093/eurpub/ckl242 | DOI Listing |
Cell Rep
January 2025
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. Electronic address:
Virus neutralization profiles against primary infection sera and corresponding antigenic cartography are integral part of the COVID-19 and influenza vaccine strain selection processes. Human single variant exposure sera have previously defined the antigenic relationships among SARS-CoV-2 variants but are now largely unavailable due to widespread population immunity. Therefore, antigenic characterization of future SARS-CoV-2 variants will require an animal model, analogous to using ferrets for influenza virus.
View Article and Find Full Text PDFTalanta
December 2024
State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, China. Electronic address:
Significant efforts were currently being made worldwide to develop a tool capable of distinguishing between various harmful viruses through simple analysis. In this study, we utilized fluorescence excitation-emission matrix (EEM) spectroscopy as a rapid and specific tool with high sensitivity, employing a straightforward methodological approach to identify spectral differences between samples of respiratory infection viruses. To achieve this goal, the fluorescence EEM spectral data from eight virus samples was divided into training and test sets, which were then analyzed using random forest and support vector machine classification models.
View Article and Find Full Text PDFVaccine
January 2025
Health and Biotechnology (SaBio), Instituto de Investigación en Recursos Cinegéticos, IREC (CSIC, UCLM, JCCM), Ronda de Toledo 12, 13005 Ciudad Real, Spain.; Center for Veterinary Health Sciences, Department of Veterinary Pathobiology, Oklahoma State University, Stillwater, OK, USA.
Clin Chem
January 2025
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, United States.
Background: Institutions of higher education (IHE) have been a focus of SARS-CoV-2 transmission studies but there is limited information on how viral diversity and transmission at IHE changed as the pandemic progressed.
Methods: Here we analyze 3606 viral genomes from unique COVID-19 episodes collected at a public university in Seattle, Washington from September 2020 to September 2022.
Results: Across the study period, we found evidence of frequent viral transmission among university affiliates with 60% (n = 2153) of viral genomes from campus specimens genetically identical to at least one other campus specimen.
Front Immunol
January 2025
Nuffield Department of Medicine, Pandemic Sciences Institute, University of Oxford, Oxford, United Kingdom.
Whereas the intranasally delivered influenza vaccines used in children affect transmission of influenza virus in the community as well as reducing illness, inactivated influenza vaccines administered by intramuscular injection do not prevent transmission and have a variable, sometimes low rate of vaccine effectiveness. Although mucosally administered vaccines have the potential to induce more protective immune response at the site of viral infection, quantitating such immune responses in large scale clinical trials and developing correlates of protection is challenging. Here we show that by using mathematical models immune responses measured in the blood after delivery of vaccine to the lungs by aerosol can predict immune responses in the respiratory tract in pigs.
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