Cryptococcus neoformans (Cn) var. grubii or Cryptococcus neoformans var. neoformans infection is usually associated with immunocompromised hosts, whereas Cryptococcusgattii more frequently causes disease in immunocompetent hosts. We examined the effects of immunodeficiency and glucocorticoid-induced immunosuppression on systemic murine infection induced by i.v. inoculation with these pathogens. SCID and immunocompetent BALB/c and C57BL/6 mice were infected with
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http://dx.doi.org/10.1080/13693780600810040 DOI Listing Publication Analysis
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Infect Immun
March 2025
Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
an invasive basidiomycete fungal pathogen, causes one of the most prevalent, life-threatening diseases in immunocompromised individuals and accounts for ~19% of AIDS-associated deaths. Therefore, understanding the pathogenesis of and its interactions with the host immune system is critical for developing therapeutics against cryptococcosis. Previous studies demonstrated that cells lacking polyphosphate (polyP), an immunomodulatory polyanionic storage molecule, display altered cell surface architecture but unimpaired virulence in a murine model of cryptococcosis.
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March 2025
Department of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, USA.
Cryptococcus deneoformans (Cd) and C. neoformans (Cn) differ in geographic prevalence and dermatotropism, with Cd strains more commonly isolated from temperate regions and skin infections. Rising global temperatures prompt concerns regarding selection for environmental fungal species with increased thermotolerance, as high mammalian temperatures provide protection against many fungal species.
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March 2025
Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, India.
DEAH box splicing helicase Prp16 in budding yeast governs spliceosomal remodelling from the branching conformation (C complex) to the exon ligation conformation (C* complex). In this study, we examined the genome-wide functions of Prp16 in the short intron-rich genome of the basidiomycete yeast . The presence of multiple introns per transcript with intronic features that are more similar to those of higher eukaryotes makes it a promising model for studying spliceosomal splicing.
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March 2025
Molecular and Cellular Biology Department, University Of Guelph, Guelph, Ontario, Canada.
The human fungal pathogen, , produces an array of virulence factors that regulate the production of a polysaccharide capsule and melanin, thermotolerance, and the release of extracellular enzymes. Here, we applied quantitative proteomics to investigate the role of CipC, a known virulence-associated protein, in the fungus.
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