Background: Posturally induced changes in minute ventilation in patients may be autonomically driven. This study aimed to test whether changes in autonomic tone with posture differed between normal and asthmatic subjects and whether this related to changes in indices of ventilation.
Methods: Ten patients with type 1 brittle asthma (BA), 10 with non-brittle, severe asthma (SA), 10 with mild asthma (MA) and 10 normal individuals were studied lying flat, at 60 degrees head up tilt and flat again each for 30min, assessing end-tidal CO(2) (ETCO(2)), respiratory rate and autonomic tone by heart rate variability.
Results: Parasympathetic tone (as high-frequency [HF] power) fell on tilt in all four groups, all showing increases in LF (low frequency)/HF ratio (sympatho-vagal balance) on tilt (BA, 2.03-4.9; SA, 3.3-8.2; MA, 1.5-4.9; normals, 2.3-6.6). ETCO(2) on tilt fell significantly in all 3 asthma groups (BA, DeltaETCO(2) -0.4, 95% CIs -0.18 to -0.75, P=0.005; SA, -0.7, 95% CIs -0.27 to -1.16, P=0.004; MA, -0.5, 95% CIs -0.14 to -0.78, P=0.01) but not in normals (-0.1, 95% CIs +0.23 to -0.49). The fall in ETCO(2) on tilt correlated with the fall in HF power in all three asthma groups but not in normal subjects.
Conclusion: Changes in vagal tone posture are seen on tilt in both normal and asthmatic subjects which relate to changes in ETCO(2) only in asthmatic subjects. This provides support for the hypothesis that hyper-ventilatory response to postural change in asthma is autonomically influenced.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.rmed.2006.08.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Real-World Effectiveness and Tolerability of Dolutegravir and Lamivudine 2-Drug Regimen in People Living with HIV: Systematic Literature Review and Meta-Analysis.
Infect Dis Ther
January 2025
ViiV Healthcare, Madrid, Spain.
Introduction: Dolutegravir (DTG) + lamivudine (3TC) demonstrated high rates of virologic suppression (VS) and low rates of virologic failure (VF), discontinuation, and drug resistance in randomized trials. Real-world evidence can support treatment effectiveness, safety, and tolerability in clinical practice and aid in treatment decisions.
Methods: A systematic literature review (SLR) was conducted to identify studies using DTG + 3TC (January 2013-March 2024).
Effect of different 3D-printing systems on the flexural strength of provisional fixed dental prostheses: a systematic review and network meta-analysis of in vitro studies.
BMC Oral Health
January 2025
Department of Restorative Dentistry, Recep Tayyip Erdoğan University, Rize, Turkey.
Objectives: The aim of this systematic review and network meta-analysis was to compare the flexural strength of provisional fixed dental prostheses (PFDPs) fabricated using different 3D printing technologies, including digital light processing (DLP), stereolithography (SLA), liquid crystal display (LCD), selective laser sintering (SLS), Digital Light Synthesis (DLS), and fused deposition modeling (FDM).
Materials And Methods: A comprehensive literature search was conducted in databases including PubMed, Web of Science, Scopus, and Open Grey up to September 2024. Studies evaluating the flexural strength of PFDPs fabricated by 3D printing systems were included.
Endometriosis does not impact aneuploidy rates of products of conception in IVF population.
Sci Rep
January 2025
Centre for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
It has been debated whether endometriosis (EMS) adversely affects oocyte quality, potentially leading to a higher incidence of genetically unbalanced embryos or other egg factors that affect the developmental potential. In this study, we explored the effects of endometriosis on risk of chromosomally aberrant in miscarried products of conception (POC) after assisted reproductive treatment (ART), including fresh and frozen cycles. Miscarried POCs were collected from EMS patients (N = 102) and non-EMS patients (N = 441).
View Article and Find Full Text PDFSex and Cardiac Operations: Are We Being Fair to Our Female Patients?
Heart Lung Circ
January 2025
Division of Cardiovascular Research, School of Medcine, University of Dundee, Ninewells Hospital, Dundee, UK. Electronic address:
Background: Research suggests that although men have a higher cardiovascular disease (CVD) rate, women with CVD are more likely to experience a poorer prognosis, possibly owing to incorrect diagnosis and poorer treatment. A question not yet addressed is whether some of this inequality could be due to sex bias when selecting patients for operation.
Method: The participants were from the Scottish Heart Health Extended Cohort who had been admitted to hospital with a cardiovascular diagnosis over the study period.
Associations of Physical Activity and Cardiorespiratory Fitness with Incident Chronic Kidney Disease in a Korean Population.
J Ren Nutr
January 2025
Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea. Electronic address:
Objective: This large cohort study aimed to examine the overall associations of physical activity (PA) and estimated cardiorespiratory fitness (eCRF) with incident chronic kidney disease (CKD).
Methods: This study included a total of 274,292 participants (mean age, 37.9±8.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!