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Prediction of ischemic stroke in patients with H-type hypertension based on biomarker.
Sci Rep
January 2025
Department of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, Anzhen Road No. 2, Chaoyang District, Beijing, 100029, China.
Hypertension combined with hyperhomocysteinemia significantly raises the risk of ischemic stroke. Our study aimed to develop and validate a biomarker-based prediction model for ischemic stroke in Hyperhomocysteinemia-type (H-type) hypertension patients. We retrospectively included 3,305 patients in the development cohort, and externally validated in 103 patients from another cohort.
View Article and Find Full Text PDFHigh penetrance and phenotypic landscape of methylenetetrahydrofolate reductase c.665 C>T polymorphism in the absence of folate fortification.
Clin Nutr ESPEN
November 2024
Yoda Diagnostics Pvt Ltd, 6-3-862/A, Lal Bungalow add on, Ameerpet, Hyderabad, India. Electronic address:
Article Synopsis
- * Analysis involved 2,431 cases and 1,265 healthy controls, revealing that individuals with the MTHFR variant had a significantly higher risk for conditions like respiratory distress, recurrent pregnancy loss, and intellectual disabilities.
- * The MTHFR TT-genotype specifically indicated a high risk of abnormal phenotypes, emphasizing the importance of this genetic variant in neurodevelopmental and other health-related outcomes.
Hyperhomocysteinemia and its Association with Cognitive Functioning-A Cross-sectional Study from an Ageing Cohort in South India.
Indian J Psychol Med
October 2024
Centre for Brain Research, Indian Institute of Science, Bengaluru, Karnataka, India.
Association between homocysteine levels and mortality in CVD: a cohort study based on NHANES database.
BMC Cardiovasc Disord
November 2024
Department of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Background: Cardiovascular disease (CVD) is a major global health concern with increasing incident cases and deaths. Homocysteine (Hcy) has been investigated for its potential association with CVD, researchers have debated the extent to which Hcy should be considered a risk factor for cardiovascular diseases, as only 50% of CVD can be explained by classical risk factors.
Methods: We conducted a prospective cohort study using NHANES 1999-2006 data, analyzing 1,739 US patients aged at least 30 with CVD.
Establishment of a prediction model for venous thromboembolism in patients with acute exacerbation of chronic obstructive pulmonary disease based on serum homocysteine levels and Wells scores: a retrospective cohort study.
BMC Cardiovasc Disord
October 2024
Department of Emergency, Shenzhen Nanshan People's Hospital, No. 89, Taoyuan Road, Nanshan District, Shenzhen, Guangdong Province, 518052, China.
Background: We evaluated the diagnostic value of homocysteine (Hcy) levels combined with the Wells score and established a prediction model for venous thromboembolism (VTE) occurrence in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) based on the Hcy level and the Wells score.
Patients And Methods: Clinical information from 914 patients with AECOPD was retrospectively collected in our hospital from June 2020 to October 2023. Receiver operating characteristic curves were plotted to evaluate the diagnostic ability of Hcy concentrations combined with Wells scores and the prediction ability of the model.
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