AI Article Synopsis
- The study investigated the link between C282Y and H63D mutations in the HFE gene and male infertility by comparing 262 infertile men to 200 fertile men.
- The results showed no significant difference in the prevalence of these mutations between the two groups.
- Therefore, the findings suggest that C282Y and H63D mutations are not risk factors for male infertility and do not relate to its clinical symptoms.
Article Abstract
The aim of this study was to find out whether C282Y and H63D mutations in the hemochromatosis (HFE) gene are associated with male infertility and whether the prevalence of the HFE mutations is higher in a group of 262 infertile men in comparison to 200 fertile men. Because the C282Y and H63D HFE gene distributions in infertile men were not significantly different from fertile controls, our data suggest that the C282Y and H63D HFE gene mutations are not risk factors for male infertility and are not associated with clinical manifestations of male infertility.
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| http://dx.doi.org/10.1016/j.fertnstert.2006.05.034 | DOI Listing |
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