Epithelial mucinosis (follicular mucinosis) is a reactive histological pattern characterized by the accumulation of mucin in the infundibular, follicular, and sebaceous epithelium, that may occur in multiple skin conditions and cannot be considered a specific disease. Alopecia mucinosa is a clinicopathological entity with distinctive skin lesions, mucin deposits in the hair follicles and periadnexal lymphoid infiltrates. Three types of mucinous alopecia have been described: idiopathic, persistent or benign chronic, and associated to lymphoma. For some authors, these types of mucinous alopecia are not independent diseases, but rather represent variants of mycosis fungoides with epithelial mucinosis.
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http://dx.doi.org/10.1016/s0001-7310(06)73453-6 | DOI Listing |
Georgian Med News
October 2023
4Hospital of Trauma Surgery, Department of Musculoskeletal Research, Marktredwitz Hospital, Germany.
Ganglion cysts in the knee region can manifest as anterior knee pain. Unlike synovial cysts, these lesions lack synovial epithelial lining and occur secondary to mucoid degeneration of connective tissue because, often in response to chronic irritation and repetitive traumas. However, an intratendinous location is a rare finding.
View Article and Find Full Text PDFInt J Mol Sci
February 2023
Department of Biochemistry & Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Mucopolysaccharidosis I-Hurler (MPS I-H) is caused by the loss of α-L-iduronidase, a lysosomal enzyme that degrades glycosaminoglycans. Current therapies cannot treat many MPS I-H manifestations. In this study, triamterene, an FDA-approved, antihypertensive diuretic, was found to suppress translation termination at a nonsense mutation associated with MPS I-H.
View Article and Find Full Text PDFJ Eur Acad Dermatol Venereol
July 2023
Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Photodiagnosis Photodyn Ther
September 2022
Department of Dermatology, Hangzhou Third People's Hospital; Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University; Affiliated Hangzhou Dermatology Hospital, Zhejiang University School of Medicine; West Lake Road 38, Hangzhou 310009, PRChina. Electronic address:
Mol Genet Metab
February 2022
Inventiva Pharma, 50 Rue de Dijon, Daix 21121, France. Electronic address:
Maroteaux - Lamy syndrome (mucopolysaccharidosis type VI, MPS VI) is a lysosomal storage disease resulting from insufficient enzymatic activity for degradation of the specific glycosaminoglycans (GAG) chondroitin sulphate (CS) and dermatan sulphate (DS). Among the most pronounced MPS VI clinical manifestations caused by cellular accumulation of excess CS and DS are eye disorders, in particular those that affect the cornea. Ocular manifestations are not treated by the current standard of care, enzyme replacement therapy (ERT), leaving patients with a significant unmet need.
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