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Ca1.3 L-type Ca channel contributes to the heartbeat by generating a dihydropyridine-sensitive persistent Na current.
Sci Rep
August 2017
Department of Physiology, Shiga University of Medical Science, Otsu Seta-Tsukinowa, Shiga, 520-2192, Japan.
The spontaneous activity of sinoatrial node (SAN) pacemaker cells is generated by a functional interplay between the activity of ionic currents of the plasma membrane and intracellular Ca dynamics. The molecular correlate of a dihydropyridine (DHP)-sensitive sustained inward Na current (I ), a key player in SAN automaticity, is still unknown. Here we show that I and the L-type Ca current (I ) share Ca1.
View Article and Find Full Text PDFGlechoma hederacea Suppresses RANKL-mediated Osteoclastogenesis.
J Dent Res
July 2014
Department of Oral Physiology, College of Dentistry, Wonkwang University, Iksan 570-749, Republic of Korea Microelectronics and Display, Next Generation Industrial Radiation Technology RIC, Wonkwang University, Iksan 570-749, Republic of Korea
Glechoma hederacea (GH), commonly known as ground-ivy or gill-over-the-ground, has been extensively used in folk remedies for relieving symptoms of inflammatory disorders. However, the molecular mechanisms underlying the therapeutic action of GH are poorly understood. Here, we demonstrate that GH constituents inhibit osteoclastogenesis by abrogating receptor activator of nuclear κ-B ligand (RANKL)-induced free cytosolic Ca(2+) ([Ca(2+)]i) oscillations.
View Article and Find Full Text PDFGenetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.
J Neurosci
May 2014
University of California, Davis, School of Medicine, Center for Neuroscience, Program in Communication Science, Davis, California 95618,
Article Synopsis
- The study investigates the role of Cav1.3 calcium channels in spiral ganglion neurons (SGNs), which connect hair cells to the cochlear nucleus, using Cav1.3-deficient mice.
- Findings show that SGNs express another channel, Cav1.2, when Cav1.3 is absent, leading to decreased firing frequency in SGNs from Cav1.3(-/-) mice compared to wild-type mice.
- The research confirms that the remaining calcium currents in Cav1.3(-/-) neurons are actually from Cav1.2 activity, highlighting the distinct functions of Cav1.2 and Cav1.3 in SGNs.
FGF-activated calcium channels control neural gene expression in Xenopus.
Biochim Biophys Acta
June 2009
Centre de biologie du développement, CNRS UMR 5547, Université Paul Sabatier, 118, route de Narbonne F 31062 Toulouse Cedex, France.
In vertebrates, the formation of the nervous system starts at gastrulation with a process called neural induction. This process requires, at least in part, the inhibition of BMP signalling in the ectoderm by noggin, as well as FGF receptor activation and Ca2+ signalling. Our studies with Xenopus embryos suggest that an increase in intracellular Ca2+ concentration ([Ca2+]i), via dihydropyridine-sensitive Ca2+ channels (DHP-sensitive Ca2+ channels) is necessary and sufficient to direct the ectodermal cells toward a neural fate, and that Ca2+ directly controls the expression of neural genes.
View Article and Find Full Text PDFL-type Ca2+ channels in mast cells: activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels.
Mol Immunol
April 2009
Division of Molecular Cell Immunology and Allergology, Advanced Medical Research Center, Nihon University Graduate School of Medical Science, 30-1 Oyaguchikami-cho Itabashi-ku, Tokyo 173-8610, Japan.
Store-operated Ca(2+) channels (SOCs) are considered to be the principal route of Ca(2+) influx in non-excitable cells. We have previously shown that in mast cells IgE+antigen (Ag) induces a dihydropyridine (DHP)-sensitive Ca(2+) influx independently of Ca(2+) store depletion. Since the DHP receptor is the alpha subunit of L-type Ca(2+) channels (LTCCs), we examined the possible role of LTCCs in mast cell activation.
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