Objective: To evaluate the clinical effects of thymectomy in treatment of myasthenia gravis: (MG).
Methods: The clinical data of 67 patients, 29 males and 38 females, aged 10.5 - 68, who underwent thymectomy were analyzed.
Results: According to the Monden's standard the overall effective rate of thymectomy was 71.6%. The remission rate was 32.8% (22/6), the improvement rate was 38.8% (26/67), 14 patients showed no change (20.9%), and deterioration was seen in 5 patients (7.5%).
Conclusion: An effective method to treat MG, thymectomy should be performed on most of the MG patients early and actively.
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Front Surg
December 2024
Division of Thoracic Surgery, Department of Surgery, Kaiser Permanente Northern California, Oakland, CA, United States.
Though advancements have been made in the pharmacologic treatment of myasthenia gravis (MG), surgical resection is not only an option as a last line of defense for those patients who do not respond to medical therapy but also remains vital for those with thymic epithelial tumors (TET). While prior studies have shown the potential superiority of minimally invasive approaches via robotic- and video-assisted thoracoscopic surgery (RATS/VATS) for thymectomy compared to open surgery, in the setting of malignancies, this outcome delineation is controversial. As RATS/VATS may be associated with less post-operative complications in the treatment of TET, some surgeons argue that the open approach is necessary for complete resection (R0 resection) and to prevent potential seeding of the malignancy.
View Article and Find Full Text PDFFront Neurol
December 2024
Center of Treatment of Myasthenia Gravis, People's Hospital of Shijiazhuang, Shijiazhuang, China.
Background And Purpose: Myasthenia gravis (MG) is characterized by fluctuating muscle weakness due to immune-mediated damage to acetylcholine receptors. Viral infections can exacerbate symptoms of muscle weakness, and the clinical status of patients with MG may influence the outcomes of such infections. Here, we identified factors of symptom exacerbation, severe SARS-CoV-2 infection, and pneumonia in patients with MG who are infected with SARS-CoV-2.
View Article and Find Full Text PDFIntern Med
December 2024
Department of Respiratory Medicine, Faculty of Life Sciences, Kumamoto University, Japan.
A 59-year-old woman presented with multiple mediastinal masses 6 months after post-thymectomy for type B2 thymoma. A diagnosis of small-cell carcinoma (SmCC) via a computed tomography-guided biopsy and fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography revealed no primary lesions outside the anterior mediastinum. The pathologically reevaluated post-thymectomy specimen showed no neuroendocrine differentiation.
View Article and Find Full Text PDFInt J Cardiol Congenit Heart Dis
March 2024
Royal Brompton and Harefield NHS Trust and Imperial College London, UK.
Aim: To highlight the potential lack of documentation of thymectomy on historic cardiac operation notes and how this impacts the safety of the yellow fever vaccination for patients who have had congenital heart surgery in childhood.
Background: With advances in treatment, the population of adults with congenital heart disease (ACHD) is ever growing. Consequently, increasing numbers of patients wish to travel and work abroad.
Indian J Thorac Cardiovasc Surg
January 2025
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Background: Traditionally, sternotomy has been the gold standard approach for the treatment of thymomas. However, interest in minimally invasive techniques such as video-assisted and robot-assisted thymectomy is gaining momentum. Concerns have been raised over the possibility of en-bloc resection using minimal access techniques due to limited working space and increased tumour manipulation leading to tumour breach and recurrence.
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