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Modern Management of Gastric Neuroendocrine Neoplasms.
Curr Treat Options Oncol
September 2024
Department of Medicine, Section of Medical Oncology, Yale School of Medicine, 25 York Street, New Haven, CT, 06510, USA.
Gastric neuroendocrine neoplasms (G-NENs) are a heterogeneous group of tumors that broadly fall into two groups. The first group, driven by oversecretion of gastrin, are generally multifocal, small, and behave indolently with a low (but non-zero) risk of progression and metastatic spread. They are conventionally categorized into type 1, with endogenous gastric-based overproduction of gastrin, and type 2 G-NEN, with overproduction of gastrin from an extra-gastric gastrin-secreting tumor.
View Article and Find Full Text PDFSpatial profiling reveals tissue-specific neuro-immune interactions in gastroenteropancreatic neuroendocrine tumors.
J Pathol
March 2024
Division of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ, USA.
Article Synopsis
- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are complex cancers influenced by the interaction of tumor cells with their surrounding microenvironment, necessitating the study of tumor-derived signals.
- Researchers utilized digital spatial profiling (DSP) to analyze the expression of immune and neural proteins in a variety of GEP-NETs, demonstrating that immune-related proteins may facilitate neuroendocrine differentiation and tumor growth.
- The findings indicated notable differences between gastrin-secreting and non-functional NETs, particularly in protein expression and immune cell presence, with MEN1-related tumors showing strong immune exclusion and unique neuro-immune signatures.
All you need to know about gastrinoma today | Gastrinoma and Zollinger-Ellison syndrome: A thorough update.
J Neuroendocrinol
April 2023
First Department of Surgery, National and Kapodistrian University of Athens, Laikon General Hospital, Athens, Greece.
Zollinger-Ellison syndrome (ZES) is a distinct syndrome characterized by hyperchlorhydria-induced peptic ulcer disease and chronic diarrhea. It is the result of a gastrin-excess state caused by a duodenal or pancreatic neuroendocrine tumor referred to as gastrinoma. This gastrin-secreting neuroendocrine tumor is usually sporadic in nature, or part of multiple endocrine neoplasia type 1 syndrome.
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