Objective: Challenge tests designed to evaluate serotoninergic pathways have widely used intravenous citalopram. Oral citalopram has also been used, but unsatisfactory results were obtained with a dose of 20 mg. The objective of this study was to determine whether a higher oral dose would reproduce similar to those described for intravenous administration. To that end, we evaluated cortisol, growth hormone and prolactin levels.
Method: Eight healthy male volunteers were evaluated in a randomized crossover challenge test with 40 mg of oral citalopram or placebo.
Results: Cortisol levels increased at 2-4h after the oral citalopram intake, with a small amplitude peak occurring in two-thirds of the subjects. Levels of prolactin and growth hormone remained unchanged throughout the study.
Conclusion: The use of oral citalopram might present an alternative in serotoninergic challenge tests, but higher doses are required.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s1516-44462006000300011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigation of Pharmacokinetic and Pharmacodynamic Interactions between Citalopram and Duloxetine: An Integrated Analytical, Computational, Behavioral, and Biochemical Approach.
ACS Pharmacol Transl Sci
December 2024
School of Biotechnology, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Despite the prevalent utilization of antidepressant combinations in clinical settings, concerns persist regarding heightened side effects and potential drug-drug interactions (DDI). In response, this study investigates the interaction between citalopram (CIT) and duloxetine (DUL) using a multifaceted approach encompassing analytical, computational, behavioral, and biochemical techniques. Notably, the absence of published analytical methods tailored for studying antidepressant interactions underscores the novelty of our endeavor.
View Article and Find Full Text PDFCan fluoxetine influence orthodontic tooth movement? A systematic review and meta-analysis of studies on animal models.
Int Orthod
December 2024
Department of Periodontics and Endodontics, School of Dental Medicine, Stony Brook University, Stony Brook, NY, 11794, United States.
Introduction: Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine adversely affect bone mineral density (BMD) and turnover, thereby increasing the risk of fractures. The objective of the present systematic review and meta-analysis was to evaluate studies on animal models that assessed whether fluoxetine can influence orthodontic tooth movement (OTM).
Material And Methods: Indexed databases (PubMed/Medline, EMBASE, Cochrane Library, Scopus and ISI Web of Knowledge) and Google Scholar were searched without time and language barriers up to and including June 2024.
Development and Evaluation of an Orodispersible Tablet Formation for the Delivery of a Hydrophobic Drug.
Adv Pharmacol Pharm Sci
October 2024
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Jadara University, Irbid 21110, Jordan.
Orodispersible tablet (ODT) is a promising avenue for drug delivery, offering a dosage form that can be disintegrated instantaneously in the mouth and released the drug that dissolves or disperses in the saliva without the addition of water. ODT can effectively boost the dissolution rate and consequently the bioavailability of several hydrophobic drugs. Additionally, ODT is very attractive and suitable for specific patients who are unable to swallow the traditional tablet.
View Article and Find Full Text PDFBruxism and Sleep Disorders in Patients Diagnosed With Depressive Disorder and Anxiety Disorder Using Antidepressants.
J Oral Rehabil
January 2025
Department of Psychiatry, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Objective: To investigate the frequency of bruxism, factors associated with bruxism and sleep disorders in patients diagnosed with depressive disorder and anxiety disorder who use antidepressants.
Methods: A total of 273 patients diagnosed with anxiety disorder or depression who had been using antidepressants for at least 1 month were included, along with 273 healthy control groups. The patient and control groups completed a sociodemographic data form, Epworth Daytime Sleepiness Scale (EDSS), Pittsburgh Sleep Quality Index (PSQI) and a bruxism questionnaire.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!