To help fulfil the objectives of prospective studies of pregnancy and human development, such as the National Children's Study, there is a need to pinpoint ovulation and conception in a cohort of women. This paper discusses the suitability of using natural and easily observed markers of ovulation for detection of the most likely day of ovulation and conception. Of the biomarkers supported by clinical data, the use of cervical mucus is emphasised as it appears most promising. A considerable amount of data suggests that observation of changes in vaginal discharge from cervical mucus can closely approximate the day of ovulation, is easy to learn and suitable for a large group of women. While this approach could also be cost-effective, a significant drawback may be the learning phase which may take 2-3 instructional sessions for women to fully identify recurring changes across the menstrual cycle.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-3016.2006.00767.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Engrailed-2 (EN2) protein in cervical mucus: a novel biomarker for endometrial carcinoma.
Clin Transl Oncol
November 2024
Institute of Cardiovascular Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Handian District, Beijing, China.
Objective: This study aims to demonstrate that the EN2 protein in cervical mucus may serve as a novel biomarker for screening endometrial cancer.
Materials And Methods: This study included 133 patients who were treated at Beijing Obstetrics and Gynecology Hospital. According to the pathological results of hysteroscopy endometrial biopsy, the patients were divided into endometrial cancer group (n = 55), endometrial atypical hyperplasia group (n = 16), benign lesion group (n = 28), and control group (n = 34).
A multi-class support vector machine classification model based on 14 microRNAs for forensic body fluid identification.
Forensic Sci Int Genet
February 2025
Institute of Forensic Medicine, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu 610041, China. Electronic address:
Article Synopsis
- MicroRNAs (miRNAs) show promise for identifying body fluids in forensics due to their stability and unique expression patterns, but their relative expression makes identification challenging.
- The study validated reference genes and selected a combination of miRNAs to create a multi-class support vector machine (MSVM) model that predicts body fluid origins with high accuracy, even for aged or mixed samples.
- Further validation across different labs is needed before implementing miRNAs in routine forensic practice.
A technical note on the Kamranmeter; a manually operated device for measuring salivary spinnbarkeit.
Clin Oral Investig
November 2024
Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands.
Objective: The objective was to develop a manually operatable, non-electric device to measure salivary spinnbarkeit for research, clinical and educational purposes.
Materials And Methods: A newly developed device, named the Kamranmeter, was built and evaluated in a pilot study, comparing the spinnbarkeit of unstimulated and chew-stimulated saliva samples from healthy volunteers. The Neva Meter, which operates on electrical resistance, was used as a reference standard.
Towards the identification of body fluids using RT-LAMP isothermal amplification coupled with CRISPR-Cas12a.
Forensic Sci Int Genet
January 2025
Forensic Research and Development Team, Institute of Environmental Science and Research Ltd, Auckland, New Zealand.
While often necessary in sexual assault cases, confirmatory identification of body fluids can be a lengthy and/or costly process. In particular, the detection of vaginal fluid and menstrual fluid in forensic casework is limited to endpoint reverse-transcription PCR to detect fluid-specific messenger RNA (mRNA) markers as there are no robust chemical or enzymatic techniques available for these fluids. Similarly, testing for rectal mucosa is not possible with standard methods, the presence of which would provide probative value in cases of alleged anal penetration, although mRNA-based markers have recently been described.
View Article and Find Full Text PDFDetecting Leptospira spp. infection in cows by PCR: What is the best sample to test?
Theriogenology
January 2025
Laboratory of Veterinary Bacteriology, Federal Fluminense University, Niterói, Brazil. Electronic address:
Bovine leptospirosis is a major reproductive disease. As cows can be leptospiral carriers both on the renal and genital tract, diagnosis can be challenging, with an underlying risk of misdiagnosis. Traditionally, the infection has been diagnosed by culturing or PCR from urine samples.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!