A 30-year-old woman presented with subacute intestinal obstruction. Clinical evaluation and radiological studies pointed toward an enteroenteric intussusception with intestinal polyps. Exploratory laparotomy revealed a retrograde intussusception mass acting as a lead point for a second prograde jejuno-jejunal intussusception. Resection and anastomosis of the involved segment was done. Histopathology revealed the presence of hamartomas. The patient was diagnosed with Peutz-Jeghers syndrome. The rarity of such a case is highlighted, and the diagnostic challenge it poses is discussed.
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