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Sp140L Is a Novel Herpesvirus Restriction Factor.
bioRxiv
December 2024
Duke University School of Medicine, Department of Molecular Genetics and Microbiology, Duke Center for Virology, Durham, NC, USA.
Herpesviruses, including the oncogenic Epstein-Barr Virus (EBV), must bypass host DNA sensing mechanisms to establish infection. The first viral latency protein expressed, EBNA-LP, is essential for transformation of naïve B cells, yet its role in evading host defenses remains unclear. Using single-cell RNA sequencing of EBNA-LP-Knockout (LPKO)-infected B cells, we reveal an antiviral response landscape implicating the 'speckled proteins' as key restriction factors countered by EBNA-LP.
View Article and Find Full Text PDFThree novel neoplasms in Nancy Ma's owl monkeys ().
Vet Pathol
December 2024
The University of Texas MD Anderson Cancer Center, Bastrop, TX.
Neoplasms are only sporadically reported in New World primates and rarely in owl monkeys (), specifically. Previous reports of neoplasms in owl monkeys are primarily restricted to lymphoma induced by infection, although other tumors in the central nervous, genitourinary, gastrointestinal, and endocrine systems have been sporadically reported. Herein, we describe 3 previously unreported neoplasms in owl monkeys () including a pericardial mesothelioma in a 6-year-old male, a nephroblastoma in a 2-year-old male, and a cervical neoplasm with characteristics of an epithelioid trophoblastic tumor in a 4-year-old female, all occurring in the same closed breeding colony at a research facility in central Texas.
View Article and Find Full Text PDFChronic upper airway inflammation related to high Th2 cytokines in Mendelian susceptibility to mycobacterial disease case.
Qatar Med J
April 2022
Laboratory of Clinical Immunology, Inflammation, and Allergy, Faculty of Medicine and Pharmacy of Casablanca, King Hassan II University, 20460 Casablanca, Morocco E-mail:
Article Synopsis
- The report discusses a child with Mendelian susceptibility to mycobacterial disease (MSMD) caused by a complete deficiency of the T-bet protein, leading to impaired production of the immune signaling molecule IFN-γ.
- The patient shows persistent upper airway inflammation and high levels of eosinophils due to excessive production of T helper 2 (Th2) cytokines like IL-5 and IL-13, which is linked to the mutant T-bet failing to regulate these cytokines.
- The study concludes that T-bet deficiency results in both the child's susceptibility to mycobacterial infections and the increased Th2 cytokine production, causing symptoms like blood eosinophilia and upper airway inflammation.
Self-Repairing Herpesvirus Saimiri Deletion Variants.
Viruses
July 2022
Institute for Infection Medicine, Christian-Albrecht University of Kiel, University Medical Center Schleswig-Holstein, Brunswiker Str. 4, 24105 Kiel, Germany.
Herpesvirus saimiri (HVS) is discussed as a possible vector in gene therapy. In order to create a self-repairing HVS vector, the F plasmid vector moiety of the bacterial artificial chromosome (BAC) was transposed via Red recombination into the virus genes or , both important for virus replication. Repetitive sequences were additionally inserted, allowing the removal of the F-derived sequences from the viral DNA genome upon reconstitution in permissive epithelial cells.
View Article and Find Full Text PDFAllosteric regulation of noncoding RNA function by microRNAs.
Nucleic Acids Res
June 2022
Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
HSUR1 and HSUR2, two noncoding RNAs expressed by the oncogenic Herpesvirus saimiri, bind host microRNAs miR-142-3p, miR-16, and miR-27 with different purposes. While binding of miR-27 to HSUR1 triggers the degradation of the microRNA, miR-16 is tethered by HSUR2 to target host mRNAs to repress their expression. Here we show that the interaction with miR-142-3p is required for the activity of both HSURs.
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