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Protected palmitic acid to mitigate milk fat depression in grazing Holstein cows in the Mexican Highlands.
Arch Anim Nutr
January 2025
Posgrado en Producción Animal. Departamento de Zootecnia, Universidad Autónoma Chapingo, Texcoco, México.
The and isomers of conjugated linoleic acid (CLA) are associated with anticancer and lipolytic effects in tissues, respectively, but in lactating cows, the latter isomer reduces the milk fat concentration, a detrimental aspect for the dairy industry, as it reduces the yield of milk derivatives. Therefore, the objective of this study was to evaluate the effect of providing protected palmitic acid (PA) to grazing lactating Holstein cows supplemented with soybean oil as a source of conjugated linoleic acid, on milk production, fat concentration and mitigation of milk fat depression. Nine multiparous Holstein cows were used, distributed in three groups of three cows each, with initial means of days in milk, live weight, milk production, and number of calvings: 124 ± 16 days, 494 ± 53 kg, 20.
View Article and Find Full Text PDFThe PI4K2A gene positively regulates lipid synthesis in bovine mammary epithelial cells and attenuates the inhibitory effect of t10,c12-CLA on lipid synthesis.
Sci Rep
January 2025
College of Animal Science and Technology, Ningxia Key Laboratory of Ruminant Molecular and Cellular Breeding, Ningxia University, Yinchuan, 750021, China.
Currently, the identification of valuable candidate genes affecting milk fat synthesis in dairy cows is still limited, and the specific regulatory mechanism is still unknown. In this study, we used primary bovine mammary epithelial cells(BMECs)as a model and utilized overexpression and knockdown techniques for the PI4K2A gene to investigate the specific mechanisms by which it regulates lipid metabolism in BMECs. We studied whether PI4K2A regulates the inhibition of trans-10, cis-12 conjugated linoleic acid (t10,c12-CLA) on lipid synthesis in BMECs.
View Article and Find Full Text PDFImpact of dysregulated microbiota-derived C18 polyunsaturated fatty acid metabolites on arthritis severity in mice with collagen-induced arthritis.
Front Immunol
January 2025
Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan.
Objective: We aimed to evaluate microbiome and microbiota-derived C18 dietary polyunsaturated fatty acids (PUFAs), such as conjugated linoleic acid (CLA), and to investigate their differences that correlate with arthritis severity in collagen-induced arthritis (CIA) mice.
Methods: On day 84 after induction, during the chronic phase of arthritis, cecal samples were analyzed using 16S rRNA sequencing, and plasma and cecal digesta were evaluated using liquid chromatography-tandem mass spectrometry. Differences in microbial composition between 10 control (Ctrl) and 29 CIA mice or between the mild and severe subgroups based on arthritis scores were identified.
This study aimed to investigate the impact of dietary soybean oil and probiotics on goat meat quality, total conjugated linoleic acids (TCLA) concentration, and nutritional quality indicators of goats. Thirty-six male crossbred goats (Anglo-Nubian♂× Thai native♀), weighing 18.3 ± 2.
View Article and Find Full Text PDFThe Combination of Resveratrol and Conjugated Linoleic Acid Dienes Enhances the Individual Effects of These Molecules on De Novo Fatty Acid Biosynthesis in 3T3-L1 Adipocytes.
Int J Mol Sci
December 2024
Department of Human Nutrition and Dietetics, University of Agriculture, Balicka 122, 30-149 Kraków, Poland.
Consuming food containing ingredients with a documented impact on lipid metabolism can help fight overweight and obesity. The simplest way to reduce the level of fatty acids is to block their synthesis or increase the rate of their degradation. This study aimed to determine the effect of resveratrol, , conjugated linoleic acid (CLA), , CLA, and various variants of their combinations on de novo fatty acid biosynthesis in 3T3-L1 adipocytes.
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