Replacement of the triazolopiperazine ring of sitagliptin (DPP-4 IC(50)=18nM) with 3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one gave dipeptidyl peptidase IV (DPP-4) inhibitor 1 which is potent (DPP-4 IC(50)=2.6nM), selective, and efficacious in an oral glucose tolerance test in mice. It was selected for extensive preclinical development as a potential back-up candidate to sitagliptin.
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| http://dx.doi.org/10.1016/j.bmcl.2006.09.099 | DOI Listing |
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Current practices in prevention, screening, and treatment of diabetes in kidney transplant recipients: European survey highlights from the ERA DESCARTES Working Group.
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Department of Nephrology-Hypertension, Antwerp University Hospital, Edegem, Belgium.
Background: Although post-transplant diabetes mellitus (PTDM) is a common complication after kidney transplantation, there are few data on prevention, optimal screening, and treatment strategies.
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The Impact of a Metformin Recall on Patient Hemoglobin A1c Levels at a VA Network.
Fed Pract
November 2024
Aptive Resources, Alexandria, Virginia.
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January 2025
Department of Healthcare Administration, Asia University, 40454 Taichung, Taiwan. Electronic address:
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View Article and Find Full Text PDFOrally administered prednisolone decreases plasma arginine vasopressin and serum copeptin concentrations in healthy dogs.
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