AI Article Synopsis
- Large genomic studies are expanding their focus from just genes and protein-coding sequences to include all genomic elements.
- The rise in comparative sequencing data has prompted new methodologies for analyzing the largely unexplored non-coding regions of the genome.
- Key challenges involve discovering, analyzing, and understanding the evolutionary roles and natural variation of non-coding DNA.
Article Abstract
The focus of large genomic studies has shifted from only looking at genes and protein-coding sequences to exploring the full set of elements in each genome. The explosion of comparative sequencing data has led to an increase in methodologies, approaches and ideas on how to analyze the unknown fraction of the genome, namely the non-protein-coding fraction. The main issues relate to the discovery, evolutionary analysis and natural variation of non-coding DNA, and the parameters that prevent us from fully understanding the properties of non-coding DNA.
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| http://dx.doi.org/10.1016/j.gde.2006.10.003 | DOI Listing |
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