AI Article Synopsis
- Chickens were successfully vaccinated in ovo with a non-replicating human adenovirus vector that targeted H5N9 avian influenza, leading to protective immunity.
- Vaccinated birds showed varying levels of protection against highly pathogenic H5N1 and H5N2 strains, with complete protection observed against H5N2.
- The vaccine's use of robotic injection allows for mass administration and improved safety, as it does not use live viruses, and it aligns well with tracking natural avian influenza infections.
Article Abstract
Protective immunity against avian influenza virus was elicited in chickens by single-dose in ovo vaccination with a non-replicating human adenovirus vector encoding an H5N9 avian influenza virus hemagglutinin. Vaccinated chickens were protected against both H5N1 (89% hemagglutinin homology; 68% protection) and H5N2 (94% hemagglutinin homology; 100% protection) highly pathogenic avian influenza virus challenges. This vaccine can be mass-administered using available robotic in ovo injectors which provide a major advantage over current vaccination regimens. In addition, this class of adenovirus-vectored vaccines can be produced rapidly with improved safety since they do not contain any replication-competent adenoviruses. Furthermore, this mode of vaccination is compatible with epidemiological surveys of natural avian influenza virus infections.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736859 | PMC |
| http://dx.doi.org/10.1016/j.vaccine.2006.09.047 | DOI Listing |
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