AI Article Synopsis
- Down syndrome (DS) patients face higher risks of infections and blood disorders, such as transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukemia (AMKL) later on.
- A study assessed cytokine levels in serum from 23 TAM and 15 AMKL patients, highlighting significant differences in inflammatory markers like IL-1beta, TNF-alpha, and IFN-gamma between DS neonates with and without TAM.
- The findings suggest that abnormal levels of these cytokines may contribute to the development of TAM, myelodysplastic syndrome (MDS), and AMKL in individuals with DS, potentially impacting conditions like liver fibrosis or myelofibrosis.
Article Abstract
Down syndrome (DS) patients are frequently complicated with infections, autoimmune phenomena and hematological disorders, including transient abnormal myelopoiesis (TAM) in infancy and acute megakaryoblastic leukaemia (AMKL) in later life. In this study, serum levels of cytokines from 23 TAM and 15 AMKL patients were examined using the highly sensitive microsphere fluorescence system. Statistical differences between DS neonates with or without TAM were found in IL-1beta [median 7.0 pg/ml (0.34-271.6) verses 0.05 pg/ml (0.0-2.4), p=0.034], TNF-alpha [8.11 pg/ml (0.1-253.0) verses 0.41 pg/ml (0.1-1.5), p=0.041], and IFN-gamma [20.0 pg/ml (0.14-406.3) verses 1.5 pg/ml (0.14-5.79), p=0.036]. Moreover, abnormal inflammatory cytokinemia was also found in myelodysplastic syndrome (MDS) and AMKL with DS. These abnormal cytokinemia may have a role in the pathophysiology of TAM, MDS and AMKL in DS, especially in liver fibrosis or myelofibrosis.
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| http://dx.doi.org/10.1016/j.leukres.2006.09.008 | DOI Listing |
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