AI Article Synopsis
- The study investigates the role of a specific TNF-alpha gene polymorphism in the development of psoriasis vulgaris, focusing on a G/A transition at position -308.
- It compares DNA from 78 psoriasis patients with 74 healthy controls using PCR-SSP to analyze the polymorphism.
- The results show no significant association between the TNF-alpha -308 polymorphism and susceptibility to psoriasis, regardless of the patient's onset type or gender.
Article Abstract
Background: Genes encoded within the MHC complex on chromosome 6 are thought to play an important role in the pathogenesis of psoriasis. A potential candidate is tumor necrosis factor alpha (TNF-alpha) gene. Psoriasis features an increased activity of the proinflammatory cytokine TNF-alpha in affected lesions. TNF-alpha promoter region contains several polymorphisms, including G/A transition at position -308, which influences transcriptional activity of TNF-alpha. This study was performed to investigate the association between TNF-alpha single nucleotide polymorphism and susceptibility for psoriasis vulgaris.
Material And Methods: DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers with no personal and family history of psoriasis was investigated. TNF-alpha promoter gene single nucleotide polymorphism (SNP) in position 308 was evaluated by PCR-SSP. The results were compared between group of psoriatic patients, divided into early onset of psoriasis (type I) and late onset of psoriasis (type II) subgroups, and healthy subjects.
Results: There were no significant differences in the polymorphism of TNF-alpha promoter -308 (genotype distribution, allele frequencies) between psoriasis patients and healthy controls. Similar results were obtained analyzing subgroups of psoriasis patients (type I and type II of psoriasis) and gender groups.
Conclusion: TNF-alpha promoter single nucleotide polymorphism (-308) is not associated with susceptibility to psoriasis vulgaris.
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