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Complications Following Self-Administration of Hyaluronic Acid Fillers: Literature Review.
Clin Cosmet Investig Dermatol
October 2020
Maxillo-Facial Surgery Unit, Multidisciplinary Department of Medicine, Surgery and Odontological Sciences, "Luigi Vanvitelli" University Hospital, Naples, Italy.
The purpose of the present study is to review published literature regarding complications following self-administration of hyaluronic acid (HA) filler. The following keywords were searched in Pubmed and Cochrane database: filler AND self injection, hyaluronic acid AND self injection; filler AND self administration; hyaluronic acid AND self administration. Two authors performed title and abstract eligibility assessment independently.
View Article and Find Full Text PDFVIROME: a standard operating procedure for analysis of viral metagenome sequences.
Stand Genomic Sci
July 2012
Delaware Biotechnology Institute, University of Delaware, Newark, DE 19711.
One consistent finding among studies using shotgun metagenomics to analyze whole viral communities is that most viral sequences show no significant homology to known sequences. Thus, bioinformatic analyses based on sequence collections such as GenBank nr, which are largely comprised of sequences from known organisms, tend to ignore a majority of sequences within most shotgun viral metagenome libraries. Here we describe a bioinformatic pipeline, the Viral Informatics Resource for Metagenome Exploration (VIROME), that emphasizes the classification of viral metagenome sequences (predicted open-reading frames) based on homology search results against both known and environmental sequences.
View Article and Find Full Text PDFHuman recombinant beta-secretase immobilized enzyme reactor for fast hits' selection and characterization from a virtual screening library.
J Pharm Biomed Anal
January 2013
Department of Drug Discovery and Development, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy.
In the present work, a human recombinant BACE1 immobilized enzyme reactor (hrBACE1-IMER) has been applied for the sensitive fast screening of 38 compounds selected through a virtual screening approach. HrBACE1-IMER was inserted into a liquid chromatograph coupled with a fluorescent detector. A fluorogenic peptide substrate (M-2420), containing the β-secretase site of the Swedish mutation of APP, was injected and cleaved in the on-line HPLC-hrBACE1-IMER system, giving rise to the fluorescent product.
View Article and Find Full Text PDFA protocol for HPLC-based activity profiling for natural products with activities against tropical parasites.
Nat Prod Commun
October 2009
Institute of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland.
HPLC based activity profiling is an effective strategy to accelerate the discovery of new hits and leads from nature. It conveniently combines the superior separation power of HPLC micro scale compound separation with miniaturized biological screening methods, and on-line and off-line spectroscopy (PDA, MS(n), HR-MS, NMR) for structure elucidation. We here describe a protocol for the discovery of natural products with antimalarial, antileishmanial and antitrypanosomal activity, from extracts libraries in 96-well format.
View Article and Find Full Text PDFSuccessful participant recruitment strategies for an online smokeless tobacco cessation program.
Nicotine Tob Res
December 2006
Oregon Research Institute, 1715 Franklin Blvd, Eugene, OR 97403, USA.
An estimated 22% of Americans currently use smokeless tobacco (ST). Most live in small towns and rural areas that offer few ST cessation resources. Approximately 94 million Americans use the Internet for health-related information, and on-line access is growing among lower-income and less-educated groups.
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