AI Article Synopsis
- Malignancy is a recognized cause of cutaneous vasculitis, with only 31 reported cases of adult malignancy-associated Henoch-Schönlein purpura (HSP) in the literature.
- The majority of affected patients are older males, averaging 60 years, with most having solid tumors such as lung cancer, multiple myeloma, and prostate cancer.
- HSP symptoms often appear soon after cancer diagnosis, prompting recommendations for evaluating older men with unexplained HSP for hidden cancers and metastatic disease in known cancer patients.
Article Abstract
Malignancy is a well-known cause of cutaneous vasculitis. The occurrence of neoplasia and Henoch-Schönlein purpura (HSP) is rare and poorly understood in adults. A total of 31 cases have been reported in the world literature of adult malignancy-associated HSP. Patients were overwhelmingly male (94%) with a mean age of 60 years and presented predominantly with solid tumors (61%). The most frequent tumors were lung (nonsmall-cell) (n = 8), multiple myeloma (n = 5), prostate (n = 5), and non-Hodgkin's lymphoma (n = 3). The majority of patients (55%) developed HSP within 1 month of cancer diagnosis or detection of metastases. We present 3 cases of adults who, in the absence of known precipitating factors, developed HSP within 2 months of diagnosis of a solid tumor or metastases. We recommend that adults, especially older men who present with unexplained HSP, be evaluated for occult neoplasm. We also advise that patients with a known history of malignancy who present with HSP be evaluated for metastatic disease.
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| http://dx.doi.org/10.1016/j.jaad.2005.10.011 | DOI Listing |
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