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Article Synopsis
- Hyperhidrosis (HH) is a condition that causes excessive sweating and significantly impacts patients' quality of life, with treatments like topical glycopyrronium bromide (GBP) being evaluated for effectiveness.
- A systematic review of four randomized controlled trials found that GBP considerably improves sweat control and overall skin quality without major side effects, although some patients did experience dry mouth.
- The study suggests that GBP is an effective option for managing primary hyperhidrosis, but more extensive research is needed to fully understand its long-term effects and integrate it into clinical practice.
A Case of Pharmacologic Anisocoria in Systemic Glycopyrrolate Use from Presumed Local Ocular Inoculation.
Neuroophthalmology
February 2024
Department of Ophthalmology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Anisocoria is a common finding in ophthalmic clinical practice. History taking and examination is critical in appropriately diagnosing and managing anisocoria, as the differential can be extensive ranging from benign to life-threatening entities. This case discusses the presentation of a 22-year-old female with a history of myopia and hyperhidrosis who presented with pharmacologic anisocoria which was presumed to be from inadvertent topical exposure to conventional glycopyrrolate tablets.
View Article and Find Full Text PDFEffect of Premedication with Glycopyrrolate on Patient Tolerance and Procedure Outcomes in Patients Undergoing Unsedated Upper Gastrointestinal Endoscopy: A Randomized Placebo-controlled Trial.
Euroasian J Hepatogastroenterol
January 2023
Department of Medical Gastroenterology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Background And Aim: An optimal topical pharyngeal anesthesia (TPA) is required for better patient tolerance and procedural outcomes of an unsedated upper gastrointestinal endoscopy (UGIE). Several additional strategies have been tried to improve patient tolerance with limited success. We hypothesized that premedication with glycopyrrolate would enhance TPA and improve patient tolerance and procedural outcomes of an unsedated UGIE.
View Article and Find Full Text PDFUrinary retention and mydriasis secondary to topical glycopyrronium for axillary hyperhidrosis.
Am J Health Syst Pharm
September 2023
Denver Health and Hospital Authority, Denver, CO.
Purpose: Glycopyrronium, also known as glycopyrrolate, is an antimuscarinic competitive inhibitor of acetylcholine widely utilized topically for its anticholinergic properties in dermatology. A single topical glycopyrronium tosylate (GT) formulation is available on the market, and prescription of this medication has become increasingly popular among dermatologists. This medication has a relatively notable adverse effect profile and carries risks that patients need to be counseled on before initiation.
View Article and Find Full Text PDFLong-term efficacy and safety of 1% glycopyrronium bromide cream in patients with severe primary axillary hyperhidrosis: Results from a Phase 3b trial.
J Eur Acad Dermatol Venereol
April 2023
Dr. August Wolff GmbH & Co. KG Arzneimittel, Bielefeld, Germany.
Background: Primary axillary hyperhidrosis (PAHH) strongly affects the patient's quality of life. To date, topical treatment options are limited. One percent glycopyrronium bromide (GPB) showed promising efficacy and safety in a pivotal 4-week Phase 3a study.
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