Case report: rapidly fatal bowel ischaemia on clozapine treatment.

BMC Psychiatry

East London and City Mental Health Trust, Department of Adult Psychiatry, Royal London Hospital, Whitechapel, London E1 1BB, UK.

Published: October 2006

Background: There have been previous reported deaths due to clozapine-induced constipation. In all these cases patients have experienced prior abdominal symptoms over a period of weeks or months.

Case Presentation: We report the sudden death due to constipation of a healthy young male patient on clozapine without any known history of prior abdominal symptoms.

Conclusion: Psychiatrists need to be alert to the medical emergencies which can occur in the context of clozapine treatment and also need to make other clinicians who may have contact with their patients aware of these.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1621059PMC
http://dx.doi.org/10.1186/1471-244X-6-43DOI Listing

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