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The yak () exhibits exceptional regional adaptability, enabling it to thrive in the distinctive ecological niches of the Qinghai-Tibet Plateau. Its survival relies on the intricate balance of its intestinal microbiome, essential for adapting to harsh environmental conditions. Despite the documented significance of bacteria and fungi in maintaining intestinal homeostasis and supporting immune functions, there is still a substantial gap in understanding how the composition and functionality of yak gut microbiota vary along altitude-temperature gradients.
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