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Membrane Proteins in Nanodiscs: Methods and Applications.
ChemMedChem
January 2025
Nankai University, State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, 94 Weijin Road, 300071, Tianjin, CHINA.
Membrane proteins, a principal class of drug targets, play indispensable roles in various biological processes and are closely associated with essential life functions. Their study, however, is complicated by their low solubility in aqueous environments and distinctive structural characteristics, necessitating a suitable native-like environment for molecular analysis. Nanodisc technology has revolutionized this field, providing biochemists with a powerful tool to stabilize membrane proteins and significantly enhance their research possibilities.
View Article and Find Full Text PDFChronic kidney disease (CKD) is a common clinical condition with significant health risks for patients and is widely recognised as a major public health concern. Laboratory medicine plays a crucial role in both diagnosing and managing CKD, as diagnosis and staging rely on estimated glomerular filtration rate (GFR) and evaluating albuminuria (or proteinuria). It was evident that the laboratory assessment of CKD in Malaysia is not standardised.
View Article and Find Full Text PDFThe Somogyi hypothesis: a parallelism with Michael Somogyi's life.
Hormones (Athens)
December 2024
Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias/University of Oviedo, Oviedo, Spain.
Michael Somogyi (Somogyi Mihály, 1883-1971) was a Hungarian biochemist who developed his scientific career in Europe and, primarily, the United States. He gave the name to the eponymous Somogyi effect or Somogyi hypothesis (in short, rebound hyperglycemia after insulin-induced hypoglycemia, particularly nocturnal), which was an axiom in the treatment of diabetes for decades. Although it is currently debated whether the Somogyi hypothesis is a real or relevant phenomenon in patients with diabetes, Somogyi's other significant career achievements are often overlooked.
View Article and Find Full Text PDFJohn Brooksby was an outstanding Scottish veterinary virologist who worked at the Pirbright Institute (Pirbright) for 40 years, including 16 as the institute's director. He devised quantitative methods for measuring neutralising antibodies and perfected a complement fixation test for the diagnosis, typing and strain differentiation of foot and mouth disease (FMD), especially when combined with neutralisation. He identified four of the seven types of FMD virus (FMDV) and many subtypes.
View Article and Find Full Text PDFLaw and Order of Colloidal Tectonics: From Molecules to Self-Assembled Colloids.
Molecules
November 2024
Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181-UCCS, Unité de Catalyse et Chimie du Solide, Lille 59000, France.
Since biochemists and biologists have progressed in understanding the mechanisms involved in living organisms, biological systems have become a source of inspiration for chemists. In this context, the concept of colloidal tectonics, describing the spontaneous formation of colloidal particles or supracolloidal structures in which the building blocks are called "tectons", has emerged. Therefore, a bottom-up edification of tectons towards (supra) colloidal structures is allowed.
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