New ganoderic acids, bioactive triterpenoid metabolites from the mushroom Ganoderma lucidum.

Nat Prod Res

Pharmanex Shanghai R&D, Building 11, Bi Po Rd, Shanghai 201203, China.

Published: September 2006

Two new lanostanoids, 7-oxo-ganoderic acid Z (1) and 15-hydroxy-ganoderic acid S (2), were isolated from a lipophilic extract of the fruiting body of Ganoderma lucidum. The structures of both compounds were established by interpretation of their spectroscopic data. Compounds 1 and 2 both exhibited inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase.

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http://dx.doi.org/10.1080/14786410600921466DOI Listing

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