The objectives of this paper on the Réseau Afrique Francophone de Télémédecine (RAFT) project are the evaluation of feasibility, potential, problems and risks of an Internet-based tele-medicine network in developing countries of Africa. The RAFT project was started in Western African countries 5 years ago and has now extended to other regions of Africa as well (i.e. Madagascar, Rwanda). A project for the development of a national tele-medicine network in Mali was initiated in 2001, extended to Mauritania in 2002 and to Morocco in 2003. By 2006, a total of nine countries are connected. The entire technical infrastructure is based on Internet technologies for medical distance learning and tele-consultations. The results are a tele-medicine network that has been in productive use for over 5 years and has enabled various collaboration channels, including North-to-South (from Europe to Africa), South-to-South (within Africa), and South-to-North (from Africa to Europe) distance learning and tele-consultations, plus many personal exchanges between the participating hospitals and Universities. It has also unveiled a set of potential problems: (a) the limited importance of North-to-South collaborations when there are major differences in the available resources or the socio-cultural contexts between the collaborating parties; (b) the risk of an induced digital divide if the periphery of the health system in developing countries is not involved in the development of the network; and (c) the need for the development of local medical content management skills. Particularly point (c) is improved through the collaboration between the various countries as professionals from the medical and the computer science field are sharing courses and resources. Personal exchanges between partners in the project are frequent, and several persons received an education at one of the partner Universities. As conclusion, we can say that the identified risks have to be taken into account when designing large-scale tele-medicine projects in developing countries. These problems can be mitigated by fostering South-South collaboration channels, by the use of satellite-based Internet connectivity in remote areas, the appreciation of local knowledge and its publication on-line. The availability of such an infrastructure also facilitates the development of other projects, courses, and local content creation.
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Sci Rep
December 2024
Department of Seafood Science and Technology, The Institute of Marine Industry, Gyeongsang National University, 2-9, Tongyeonghaean-ro, Tongyeong-si, 53064, Gyeongsangnam-do, Republic of Korea.
Ulva intestinalis (UI) is widely available edible seaweed and has potential to be introduced as functional food items in Bangladesh. However, potential health hazards of this seaweed with biotoxicity assays and its relation to heavy metal contents were not evaluated previously. With these objectives, toxic effects of UI collected from floating raft culture in Monkhali Beach was evaluated using various organisms such as Chlorella vulgaris, Artemia salina, Daphnia magna, and Lactuca sativa.
View Article and Find Full Text PDFPolymers (Basel)
November 2024
División de Física Aplicada, Centro de Investigación Científica y Educación Superior de Ensenada, Ensenada 22860, Mexico.
A series of copolymers containing a thermo-responsive biocompatible first block of poly[di(ethylene glycol) methyl ether methacrylate)--(oligo(ethylene glycol) methyl ether methacrylate], P(DEGMA--OEGMA) were chain-extended to incorporate either poly(-isopropylacrylamide), PNIPAAm or poly(-isopropylacrylamide--butyl acrylate), P(NIPAAm-co-BA) as second thermo-responsive block using reversible addition-fragmentation chain transfer (RAFT) polymerization. P(DEGMA--OEGMA)--PNIPAAm copolymers showed two response temperatures at 33 and 43 °C in an aqueous solution forming stable aggregates at 37 °C. In contrast, P(DEGMA--OEGMA)--P(NIPAAm--BA) copolymers showed aggregation below room temperature due to the shift in response temperature provoked by the presence of hydrophobic butyl acrylate (BA) units, and shrinkage upon heating up to body temperature, while maintaining the second response temperature above 40 °C.
View Article and Find Full Text PDFPathogens
November 2024
College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi 830052, China.
() is capable of causing pneumonia, arthritis, mastitis, and various other ailments in cattle of all age groups, posing a significant threat to the healthy progression of the worldwide cattle industry. The invasion of non-phagocytic host cells serves as a pivotal mechanism enabling to evade the immune system and penetrate mucosal barriers, thereby promoting its spread. To investigate the differences in invasion into four types of non-phagocytic cells (Madin-Darby bovine kidney (MDBK) cells, embryonic bovine lung (EBL) cells, bovine embryo tracheal (EBTr) cells and bovine turbinate (BT) cells) and further elucidate its invasion mechanism, this study first optimized the experimental methods for invasion into cells.
View Article and Find Full Text PDFGlycobiology
December 2024
Institute for Glyco-core Research (iGCORE), Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
It remains a mystery why nature evolved the unique structural characteristics of GPI-anchored proteins (GPI-APs) and continues to sustain the complex, energy-intensive process of synthesizing these proteins. GPI-APs, despite their small size, rely on the coordinated activity of nearly 30 genes for their synthesis and remodeling, raising important evolutionary questions. The biological advantages of GPI-APs lie in their ability to rapidly redistribute across the cell membrane, localize within lipid rafts, utilize unique intracellular trafficking pathways, and function as both membrane-bound and soluble proteins.
View Article and Find Full Text PDFAnal Bioanal Chem
January 2025
School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, PR China.
The instability of the signal intensity of fluorescent biosensors and the false signals have been significant factors affecting the performance of biosensors. Herein, a novel signaling system is devised through the application of reversible addition-fragmentation chain transfer (RAFT) polymerization with monomers containing the tetraphenylethylene (TPE) groups. TPE exhibits an aggregation-induced emission (AIE) phenomenon in certain solvents, mainly due to the blockage of the rotation of its four benzene rings, which also exist in the aggregated state.
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