The Tail Suspension Test (TST) is a commonly used screening method for antidepressants properties of drugs in mice. To date, immobility in the TST was scored live, by an observer, or automatically, using devices in which mouse movements were detected by a strain gauge. In this study we tested whether the EthoVision video analysis system can be used reliably and accurately for automatic recording and scoring of duration of immobility in the TST. First, the duration of immobility in two mouse lines was assessed. Different mobility thresholds of the video analysis system were applied and the results compared with the duration of immobility scored manually. Next, the selected immobility threshold was applied to determine the dose-response curves for the drug venlafaxine. Finally, scores from the video analysis system were compared with scores generated by an electromechanical strain gauge device (Med Associates) and a human rater. It was found that the EthoVision system could reliably and accurately quantify the duration of immobility in the TST. The best setup was an immobility threshold ranging from 2 to 3 percentage change in the object area. The EthoVision system was effective in detecting the differences between the mouse lines and the dose response to venlafaxine. The results obtained using the video analysis system were similar to the scores yielded by a human rater and the strain gauge device.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.pbb.2006.08.016 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring neuroanatomy and neuropsychology in digital financial decision-making: betrayal aversion and risk behavior.
Brain Imaging Behav
January 2025
Faculty of Economics and Business, University of Granada, Campus Universitario de Cartuja, Granada, CP, 18071, Spain.
Detecting the factors associated with financial decision-making is an unresolved challenge when trying to predict digital financial behavior. This paper reports experimental results on both neuropsychological and neuronal correlates of risk-taking and betrayal aversion among 121 healthy participants (X=21.7; SD = 2.
View Article and Find Full Text PDFObjective assessment of acute pain in foals using a facial expression-based pain scale.
Equine Vet J
January 2025
Department of Veterinary Medical Sciences, University of Bologna, Bologna, Italy.
Background: Pain assessment based on facial expressions has been described in foals.
Objectives: To extend previous pilot findings of the Equine Utrecht University Scale for Facial Assessment of Pain in Foals (EQUUS-FAP FOAL).
Study Design: Prospective blinded case-control study (known groups analysis).
Is it in their words? Teachers' enthusiasm and their natural language in class-A sentiment analysis approach.
Br J Educ Psychol
January 2025
DIPF|Leibniz Institute for Research and Information in Education, Frankfurt, Germany.
Introduction: Teacher enthusiasm is an undisputedly important characteristic of teachers, with demonstrated positive effects on student outcomes. Existing research typically operationalised teacher enthusiasm via trait-based teacher- or student ratings. Strikingly little is known about how teachers' trait enthusiasm manifests in their actual in-situ classroom behaviour.
View Article and Find Full Text PDFVirtual laboratories complement but should not replace face-to-face classes: Perceptions of life science students at Dundalk Institute of Technology, Ireland.
Adv Physiol Educ
January 2025
Department of Life & Health Sciences, Dundalk Institute of Technology, Dublin Road, Dundalk, Co. Louth, Ireland.
Virtual laboratories (VLs) enable students to experiment, analyze data or interact with digital content in a non-physical space. VLs include simulations, electronic notebooks, videos and augmented reality. As part of the 'VL Project', comprising 5 academic institutions in Ireland, we sought to determine how VLs might enhance practical learning in undergraduate life science students at Dundalk Institute of Technology (DkIT).
View Article and Find Full Text PDFQuantitative analysis of 'virtual' SSP assessment clinics in the NHS bowel cancer screening programme in England.
J Public Health (Oxf)
January 2025
NHS England London, Wellington House, 133-135 Waterloo Road, London SE1 8UG, UK.
Background: Bowel cancer screening in England is initially carried out using a home testing kit, with those who require further testing first being referred to an assessment clinic. During COVID-19, these assessment clinics became 'virtual' (telephone or video-call) where previously they had only been held face-to-face.
Methodology: A before and after study design was constructed to examine the impact of this change in clinic type on key programme metrics.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!