What makes a person, event, or object memorable? Enhanced memory for oddball items is long established, but the basis for these effects is not well understood. The present work clarifies the roles of isolation and differentiation in establishing new memories. According to the isolation account, items that are highly dissimilar to other items are better remembered. In contrast, recent category learning studies suggest that oddball items are better remembered because they must be differentiated from similar items. The present work pits the differentiation and isolation accounts against each other. The results suggest that differentiation, not isolation, leads to more accurate memory for deviant items. In contrast, gains for isolated items are attributable to reduced confusion with other items, as opposed to preferential storage.
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Sci Rep
January 2025
School of Mathematics and Statistics, Central South University, Changsha, 410083, China.
The coronavirus disease 2019 (COVID-19) interventions in interrupting transmission have paid heavy losses politically and economically. The Chinese government has replaced scaling up testing with monitoring focus groups and randomly supervising sampling, encouraging scientific research on the COVID-19 transmission curve to be confirmed by constructing epidemiological models, which include statistical models, computer simulations, mathematical illustrations of the pathogen and its effects, and several other methodologies. Although predicting and forecasting the propagation of COVID-19 are valuable, they nevertheless present an enormous challenge.
View Article and Find Full Text PDFBMC Genomics
January 2025
School of Life Sciences, Yunnan Normal University, Kunming, 650000, China.
Background: Pseudogalium is a new monotypic genus with two subspecies in China and one in Japan, which holds a distinctive phylogenetic position and ecological significance within the tribe Rubieae. Chloroplast genomes contain abundant information for resolving phylogenetic relationships. To investigate the phylogenetics of P.
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan, Republic of Korea.
Marine invertebrates such as sponges, cnidarians, bryozoans, and tunicates are considered to be prolific sources of novel biologically active natural products. Specimens from these organisms are composed of soft tissues with a high water and inorganic salt content compared to those from terrestrial counterparts. In addition, some of the secondary metabolites from these organisms tend to be more polar than those of terrestrial.
View Article and Find Full Text PDFCell Mol Gastroenterol Hepatol
January 2025
Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Department of Pediatrics, Perelman School of Medicine at University of Pennsylvania. Electronic address:
Background & Aims: Eosinophilic esophagitis (EoE) is a chronic esophageal inflammatory disorder characterized by eosinophil-rich mucosal inflammation and tissue remodeling. Prior research has revealed the upregulation of interferon (IFN) response signature genes (ISGs) in biopsy tissue from EoE patients, but the specific cell types that contribute to this IFN response and the effect of interferons on the esophageal epithelium remain incompletely understood. Here, we use scRNA-seq to examine the expression of IFN and ISGs during EoE and explore how IFN-α and IFN-γ treatments affect epithelial function.
View Article and Find Full Text PDFPLoS Biol
January 2025
Institute for Biological Physics, University of Cologne, Cologne, Germany.
Type 4 pili (T4P) are multifunctional filaments involved in adhesion, surface motility, biofilm formation, and horizontal gene transfer. These extracellular polymers are surface-exposed and, therefore, act as antigens. The human pathogen Neisseria gonorrhoeae uses pilin antigenic variation to escape immune surveillance, yet it is unclear how antigenic variation impacts most other functions of T4P.
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