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Long-term use of low-dose aspirin for cancer prevention: A 20-year longitudinal cohort study of 1,506,525 Hong Kong residents.
Int J Cancer
January 2025
Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR.
Long-term use of low-dose aspirin has been demonstrated to reduce cancer risk, but the duration of necessary medication use remains uncertain. This study aimed to investigate the long-term chemoprotective effect of aspirin among the Chinese population. This population-based study included all aspirin users between 2000 and 2019.
View Article and Find Full Text PDFGlucosinolates and Their Hydrolytic Derivatives: Promising Phytochemicals With Anticancer Potential.
Phytother Res
December 2024
Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Recent research has increasingly focused on phytochemicals as promising anticancer agents, with glucosinolates (GSLs) and their hydrolytic derivatives playing a central role. These sulfur-containing compounds, found in plants of the Brassicales order, are converted by myrosinase enzymes into biologically active products, primarily isothiocyanates (ITCs) and indoles, which exhibit significant anticancer properties. Indole-3-carbinol, diindolylmethane, sulforaphane (SFN), phenethyl isothiocyanate (PEITC), benzyl isothiocyanate, and allyl isothiocyanate have shown potent anticancer effects in animal models, particularly in breast, prostate, lung, melanoma, bladder, hepatoma, and gastrointestinal cancers.
View Article and Find Full Text PDFTherapeutic role of naringin in cancer: molecular pathways, synergy with other agents, and nanocarrier innovations.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Faculty of Pharmacy, Lloyd Institute of Management and Technology, Greater Noida, 201308, India.
Naringin, a flavanone glycoside found abundantly in citrus fruits, is well-known for its various pharmacological properties, particularly its significant anticancer effects. Research, both in vitro and in vivo, has shown that naringin is effective against several types of cancer, including liver, breast, thyroid, prostate, colon, bladder, cervical, lung, ovarian, brain, melanoma, and leukemia. Its anticancer properties are mediated through multiple mechanisms, such as apoptosis induction, inhibition of cell proliferation, cell cycle arrest, and suppression of angiogenesis, metastasis, and invasion, all while exhibiting minimal toxicity and adverse effects.
View Article and Find Full Text PDFGold standard nephroureterectomy, chemoprophylaxis and surveillance in upper tract urothelial carcinoma.
Curr Opin Urol
January 2025
Department of Genitourinary Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
Purpose Of Review: The purpose of this review is to summarize the most recent evidence on surgical management, strategies to reduce tumor recurrence, and surveillance regimens in patients diagnosed with upper tract urothelial carcinoma (UTUC) and elected for radical treatment.
Recent Findings: Minimally invasive surgery is gaining momentum in the surgical management of UTUC. Chemoprophylaxis is still the gold standard to reduce intravesical recurrence after radical nephroureterectomy (RNU).
Primary vesicoureteral reflux.
Nat Rev Dis Primers
October 2024
Departments of Paediatrics (Nephrology) and Urology, Wayne State University School of Medicine, Detroit, MI, USA.
Article Synopsis
- Primary vesicoureteral reflux (VUR) is a common condition in children where urine flows backward from the bladder, leading to urinary tract infections and potential kidney damage.
- The primary goals for treating VUR in kids are to prevent UTIs and reduce the risk of kidney problems, with available management options including antibiotics, surveillance, and various surgical techniques.
- Ongoing debates focus on the timing of imaging tests and identifying which patients will benefit most from either antibiotics or surgical treatments, with new technologies like artificial intelligence offering future support in decision-making.
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