The Baylis-Hillman approach to quinoline derivatives.

Org Biomol Chem

Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa.

Published: November 2006

Baylis-Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed.

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http://dx.doi.org/10.1039/b608592jDOI Listing

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