Objectives: This in vitro study aimed to investigate the accuracy of an electrical method for the evaluation of microleakage by a three-dimensional analysis of dye penetration.
Methods: Coronal cavities were prepared on buccal, palatal or lingual surfaces in extracted human molars. The cavities were then filled with resin composites and were subjected to 10,000 load cycles (425g). Before cavity preparation and after load cycling, physiological saline was applied and wiped off, and the change in conductance was measured across the margin of the restoration in each specimen. After dye penetration, the specimens were reduced by 100 microm in a direction parallel to the cavity floor, from the surface of the restoration to the cavity floor. The sequence of reducing the sections by 100 microm and image taking was repeated. Three-dimensional images of dye penetration were made and the proportions of the interface showing penetration were calculated.
Results: Pearson's correlation coefficients between changes in conductance and the surface area of dye penetration, between these and the rate of dye penetration, and between these and the depth of dye penetration were 0.932, 0.920 and 0.732, respectively. The correlations were significant (p<0.05).
Conclusions: The results of this electrical method for microleakage evaluation showed stronger correlations with the three-dimensional amount of marginal leakage (surface area of dye penetration and rate of dye penetration) than the two-dimensional amount (depth of dye penetration).
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http://dx.doi.org/10.1016/j.jdent.2006.09.003 | DOI Listing |
Clin Oral Investig
January 2025
Department of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN, Brazil.
Objectives: This study aimed to determine whether incorporating nanostructured additives into bleaching agents enhances efficacy and reduces side effects while identifying gaps for further investigation.
Methods: A comprehensive search was conducted in electronic databases, including PubMed/Medline, Embase, Scopus, and ISI Web of Science. Two reviewers independently screened articles based on predefined criteria, resolving discrepancies through discussion or consultation with a third reviewer.
Photobiomodul Photomed Laser Surg
January 2025
Department of Preventive Dental Sciences, College of Dentistry, Dar Al Uloom University, Riyadh, Saudi Arabia.
Impact of surface conditioner phytic acid (IP6) Er,Cr:YSGG laser (ECYL) methylene blue photodynamic therapy (MB-PDT) on the microleakage and shear bond strength (SBS) of resin-modified glass ionomer cement (RMGIC) to primary sound dentin. Overall, 80 extracted sound primary molars were collected followed by their submergence in self-cure acrylic resin. The dentin surface was exposed and made flat and was assigned into four groups based on the surface conditioning.
View Article and Find Full Text PDFSmall
January 2025
Institute of Optical Materials and Chemical Biology, Guangxi Key Laboratory of Electrochemical Energy Materials, School of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi, 530004, P. R. China.
Although classical fluorescent dyes feature advantages of high quantum yield, tunable "OFF-ON" fluorescence, and modifiable chemical structures, etc., their bio-applications in deep tissue remains challenging due to their excessively short emission wavelength (that may lead to superficial tissue penetration depth). Therefore, there is a pressing need for pushing the wavelength of classical dyes from visible region to NIR-II window.
View Article and Find Full Text PDFBiomaterials
January 2025
Joint Laboratory of Opto-Functional Theranostics in Medicine and Chemistry, The First Hospital of Jilin University, Changchun, 130021, PR China; State Key Laboratory of Supramolecular Structure and Materials, Center for Supramolecular Chemical Biology, College of Chemistry, Jilin University, Changchun, 130012, PR China. Electronic address:
The kidney, vital for metabolic balance, faces risks of severe diseases if dysfunctional. The glomerular filtration barrier (GFB), crucial for blood filtration, disrupts in conditions like diabetic nephropathy or nephritides, resulting in proteinuria or even renal failure. Monitoring GFB integrity is essential for early diagnosis or prognostic monitoring.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Research Unit on Computational Biology and Drug Design, Children's Hospital of Mexico Federico Gómez, Mexico City 06720, Mexico.
Cell-penetrating peptides (CPPs) offer a unique and efficient mechanism for delivering therapeutic agents directly into cancer cells. These peptides can traverse cellular membranes, overcoming one of the critical barriers in drug delivery systems. In this review, we explore recent advancements in the application of CPPs for cancer treatment, focusing on mechanisms, delivery strategies, and clinical potential.
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