Aim: To assess the effectiveness of oral baclofen in reducing spasticity and improving function in children with cerebral palsy.
Methods: A double-blind, randomised cross-over pilot study of oral baclofen versus placebo. Assessment tools included the Goal Attainment Scale, Pediatric Evaluation of Disability Inventory, Modified Tardieu Scale and parent questionnaire.
Results: Fifteen children with mean age 7.4 years (SD=2.7 years) and spastic or spastic/dystonic quadriplegia (Gross Motor Function Classification System Level IV or V) were enrolled. Children scored significantly better on the Goal Attainment Scale with baclofen compared with placebo (F(1,13)=4.5, P=0.05). There was no significant difference between baclofen and placebo for the Pediatric Evaluation of Disability Inventory or Modified Tardieu Scale. Parent questionnaire results are described.
Conclusion: This pilot study demonstrates that oral baclofen has an effect beyond placebo in improving goal-oriented tasks, such as transfers, in children with spastic quadriplegic cerebral palsy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1440-1754.2006.00957.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Action of GABAB receptor on local network oscillation in somatosensory cortex of oral part: focusing on NMDA receptor.
J Physiol Sci
January 2025
Department of Molecular Oral Physiology, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto, 770-8504, Tokushima, Japan. Electronic address:
The balance of activity between glutamatergic and GABAergic networks is particularly important for oscillatory neural activities in the brain. Here, we investigated the roles of GABA receptors in network oscillation in the oral somatosensory cortex (OSC), focusing on NMDA receptors. Neural oscillation at the frequency of 8-10 Hz was elicited in rat brain slices after caffeine application.
View Article and Find Full Text PDFPharmacovigilance insights into medication-induced risk of dural arteriovenous fistula.
Int J Surg
January 2025
Department of Orthopedics, Civil Aviation General Hospital, Beijing, China.
Background: Dural arteriovenous fistulas (DAVFs) pose a significant health threat owing to their high misdiagnosis rate. Case reports suggest that DAVFs or related acute events may follow medication use; however, drug-related risk factors remain unclear. In clinical practice, the concomitant use of multiple drugs for therapy is known as "polypharmacy situations," further increasing the risk of drug-induced DAVF.
View Article and Find Full Text PDFPost-Stroke Spasticity Treatment: A Retrospective Cohort Study From Alberta, Canada.
Can J Neurol Sci
November 2024
Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Article Synopsis
- A retrospective cohort study analyzed post-stroke spasticity (PSS) treatment data from Alberta, Canada, focusing on patients who started PSS treatment between 2012 and 2019.
- The most common treatment was oral baclofen, prescribed mainly by primary care physicians, with a median start time of 348 days after the stroke.
- The study highlighted issues such as over-reliance on oral baclofen (which has side effects) and underutilization of focal botulinum toxin injections, indicating a need for better alignment with treatment guidelines to improve patient outcomes.
Baclofen-related deaths in Australia 2000-2022.
Forensic Sci Int
December 2024
National Drug & Alcohol Research Centre, University of New South Wales, NSW 2052, Australia.
Article Synopsis
- Baclofen, prescribed for muscle spasms in Australia, has been linked to 102 deaths from 2000-2022, with a majority involving intentional toxicity and a significant presence of mental health and substance use issues among victims.
- The average age of those who died was about 45.6 years, with 51% being male, and 73.5% had documented mental health problems.
- The study highlights the importance of caution in prescribing baclofen due to its potential for misuse, dependency, and overdose.
Replacing hospital nurse consultations with home-based nurse consultations for severe spasticity patients on intrathecal baclofen: a qualitative study.
Disabil Rehabil
October 2024
Department of Oral and Maxillofacial Surgery, Odense University Hospital, Odense, Denmark.
Aim: This qualitative study explored the experiences of patients, caregivers and healthcare professionals after replacing hospital consultations with a home service solution for patients treated for severe spasticity with intrathecal baclofen.
Method: Semi-structured interviews were conducted with six patients, six caregivers and six healthcare professionals. The data were analysed using interpretative phenomenological analysis.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!