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Recent developments in pillar[5]arene-based nanomaterials for cancer therapy.
Chem Commun (Camb)
January 2025
School of Chemistry and Chemical Engineering, Nantong University, Nantong, Jiangsu 226019, P. R. China.
Nanomaterials possess unique size characteristics, enabling them to cross tissue gaps, penetrate the blood-brain barrier and endothelial cells, and release drugs at the cellular level. Additionally, the surface of nanomaterials is readily functionalized, endowing them with good biocompatibility, low biotoxicity, and specific targeting. All these advantages render nanomaterials broad application prospects in tumor therapy.
View Article and Find Full Text PDFGram Negative Biofilms: Structural and Functional Responses to Destruction by Antibiotic-Loaded Mixed Polymeric Micelles.
Microorganisms
December 2024
Department of Microbiology, Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Akad. G. Bonchev Street, bl. 26, 1113 Sofia, Bulgaria.
Biofilms are a well-known multifactorial virulence factor with a pivotal role in chronic bacterial infections. Their pathogenicity is determined by the combination of strain-specific mechanisms of virulence and the biofilm extracellular matrix (ECM) protecting the bacteria from the host immune defense and the action of antibacterials. The successful antibiofilm agents should combine antibacterial activity and good biocompatibility with the capacity to penetrate through the ECM.
View Article and Find Full Text PDFAntimicrobial Susceptibility Patterns and Antimicrobial Therapy of Infections Caused by Species.
Medicina (Kaunas)
December 2024
Department of Internal medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
: species have become significant sources of infections acquired in hospital settings and are commonly linked to high mortality rates. Antimicrobial resistance can be influenced by species, geographical location, antimicrobial susceptibility testing methods, and the time of bacterial isolation. There are distinct antimicrobial susceptibility patterns among species, and the investigation into potential antibiotic susceptibility variations among species is beneficial.
View Article and Find Full Text PDFEvaluating the ability of large language models to emulate personality.
Sci Rep
January 2025
Shanghai Institute of AI for Education, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, China.
For social sciences, recent advancements in Large Language Models (LLMs) have the potential to revolutionize the study of human behaviors by facilitating the creation of realistic agents characterized by a diverse range of individual differences. This research presents novel simulation studies assessing GPT-4's ability to role-play real-world individuals with diverse big five personality profiles. In simulation 1, emulated personality responses exhibited superior internal consistency, but also a more distinct and structured factor organization compared to the human counterparts they were based on.
View Article and Find Full Text PDFSteering acidic oxygen reduction selectivity of single-atom catalysts through the second sphere effect.
Nat Commun
December 2024
Center of Artificial Photosynthesis for Solar Fuels and Department of Chemistry, School of Science, Westlake University, Hangzhou, China.
Natural enzymes feature distinctive second spheres near their active sites, leading to exquisite catalytic reactivity. However, incumbent synthetic strategies offer limited versatility in functionalizing the second spheres of heterogeneous catalysts. Here, we prepare an enzyme-mimetic single Co-N atom catalyst with an elaborately configured pendant amine group in the second sphere via 1,3-dipolar cycloaddition, which switches the oxygen reduction reaction selectivity from the 4e to the 2e pathway under acidic conditions.
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