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Stimulation of Epithelial Sodium Channels in Endothelial Cells by Bone Morphogenetic Protein-4 Contributes to Salt-Sensitive Hypertension in Rats.
Oxid Med Cell Longev
May 2021
Departments of Clinical Pharmacy and Cardiology, Harbin Medical University Cancer Hospital, Institute of Metabolic Disease, Heilongjiang Academy of Medical Science, Key Laboratories of Education Ministry for Myocardial Ischemia Mechanism and Treatment, Harbin 150081, China.
Previous studies have shown that high salt induces artery stiffness by causing endothelial dysfunction via increased sodium influx. We used our unique split-open artery technique combined with protein biochemistry and measurement of vascular tone to test a hypothesis that bone morphogenetic protein 4 (BMP4) mediates high salt-induced loss of vascular relaxation by stimulating the epithelial sodium channel (ENaC) in endothelial cells. The data show that high salt intake increased BMP4 both in endothelial cells and in the serum and that exogenous BMP4 stimulated ENaC in endothelial cells.
View Article and Find Full Text PDFPercutaneous revascularization and long term clinical outcomes of diabetic patients randomized in the Occluded Artery Trial (OAT).
Int J Cardiol
October 2013
Peter Munk Cardiac Centre, University Heath Network, Toronto, Ontario, Canada.
Background: Percutaneous coronary intervention (PCI) of a persistently totally occluded infarct-related artery (IRA) in stable high-risk patients >24h after myocardial infarction (MI) does not reduce the occurrence of death, re-infarction, or heart failure. Diabetic patients are at higher risk for cardiovascular events; we examined their outcomes overall with PCI and optimal medical therapy alone (MED).
Methods: The long-term (7-year) outcomes of 454 diabetic patients (20.
Another open artery hypothesis: radial patency is the next frontier.
Catheter Cardiovasc Interv
January 2012
Medical reversal, clinical trials, and the "late" open artery hypothesis in acute myocardial infarction.
Arch Intern Med
October 2011
University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
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