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Teriflunomide-related development of inverse psoriasis and worsening of pre-existing plaque psoriasis.
Dermatol Online J
August 2024
Department of Dermatology, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA Department of Dermatology, Tulane University, New Orleans, Louisiana, USA.
Leflunomide can be used in management of psoriatic disease. Leflunomide's active metabolite, teriflunomide, is used in the treatment of multiple sclerosis and has unexpectedly been rarely reported to induce pustular psoriasis. In this report, we present a patient with multiple sclerosis who developed inverse psoriasis after starting teriflunomide.
View Article and Find Full Text PDFLeflunomide-Induced Weight Loss: Involvement of DAHPS Activity and Synthesis of Aromatic Amino Acids.
Metabolites
November 2024
School of Medicine and Health, Wuhan Polytechnic University, Wuhan 430023, China.
Article Synopsis
- Leflunomide is an immunosuppressant used to treat conditions like rheumatoid arthritis and lupus nephritis but has been linked to serious side effects such as weight loss and liver injury.
- In a mouse study, leflunomide administration resulted in significant weight loss and altered liver metabolism, particularly affecting aromatic amino acids like phenylalanine, tyrosine, and tryptophan.
- The drug was found to disrupt gut microbiota metabolism and induce liver stress through the PERK pathway, potentially explaining the weight loss and liver damage observed in patients.
Advances in the management of psoriatic arthritis in adults.
BMJ
November 2024
University of Toronto, Psoriatic Arthritis Program, University Health Network, Toronto Western Hospital, Toronto, ON, Canada
Article Synopsis
- * Management starts with assessing the patient's skin and joints while screening for other health issues, followed by a mix of therapies like education, lifestyle changes, and physiotherapy.
- * Treatment options include non-steroidal anti-inflammatory drugs and disease-modifying therapies such as methotrexate and biologics, but there’s a need for better biomarkers to personalize these treatments for each patient.
Leflunomide induced fatal dress syndrome need liver transplantation.
Hepatol Forum
September 2024
Department of Gastroenterology, Inonu University School of Medicine, Malatya, Turkiye.
Article Synopsis
- DRESS syndrome is a serious allergic reaction to drugs leading to severe blood and organ issues, which may include symptoms like skin rashes and organ failure.* -
- A 36-year-old woman developed DRESS syndrome after starting Leflunomide for psoriatic arthritis, resulting in bloody diarrhea, skin rashes, and severe liver failure.* -
- Despite undergoing a liver transplant from her son, the patient unfortunately passed away two days later due to multiple organ failures, highlighting the high mortality rate associated with DRESS syndrome.*
The prevalence and clinical features of leflunomide-associated peripheral neuropathy in patients with rheumatic disease in a New Zealand cohort.
Int J Rheum Dis
September 2024
Department of Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Objective: To identify the prevalence and clinical features of leflunomide-associated peripheral neuropathy in patients with rheumatic disease over a 42-month observational period between January 1, 2016 and June 30, 2019.
Methods: A retrospective observational study was conducted using regional prescription data identifying all patients treated with leflunomide for rheumatic diseases in the Southern District Health Board of New Zealand. Medical records were used to identify patients who developed peripheral neuropathy while receiving treatment with leflunomide.
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