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Modeling the within-host dynamics of hypnozoite activation: An analysis of the SPf66 vaccine trial.
Proc Natl Acad Sci U S A
December 2024
Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, United Kingdom.
parasites can lie dormant in the liver as hypnozoites, activating weeks to months after sporozoite inoculation to cause relapsing malarial illness. It is not known what biological processes govern hypnozoite activation. We use longitudinal data from the most detailed cohort study ever conducted in an area where both and were endemic to fit a simple within-host mathematical model of hypnozoite activation.
View Article and Find Full Text PDFRecent advances in the development of a chemically synthesised anti-malarial vaccine.
Expert Opin Biol Ther
June 2016
a 1 Fundación Instituto de Inmunología de Colombia (FIDIC) , Carrera 50 # 26-20, Bogotá, Colombia +57 1 4815219 ; +57 1 4815269 ;
Introduction: Obtaining an effective antimalarial vaccine has represented one of the biggest public health challenges over the last 50 years. Despite efforts by many laboratories around the world using whole-organism, recombinant proteins and genome-based approaches, the results have been disappointing. One of the main problems when designing an antimalarial vaccine is the poor immunogenicity induced by the functionally relevant and conserved protein regions of the parasite.
View Article and Find Full Text PDFDesigning improved poly lactic-co-glycolic acid microspheres for a malarial vaccine: incorporation of alginate and polyinosinic-polycytidilic acid.
J Microencapsul
May 2015
NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country, Vitoria, Spain and.
Vaccination using proteins and peptides is currently gaining importance. One of the major drawbacks of this approach is the lack of an efficient immune response when the antigens are administered without adjuvants. In this study, we have taken the advantage of a combined adjuvant system in order to improve the immunogenicity of the SPf66 malarial antigen.
View Article and Find Full Text PDFEnhancing immunogenicity to PLGA microparticulate systems by incorporation of alginate and RGD-modified alginate.
Eur J Pharm Sci
September 2011
NanoBioCel Group, Laboratory of Pharmaceutics, University of the Basque Country, School of Pharmacy, Vitoria-Gasteiz, Spain.
Poly-lactide-co-glycolide acid (PLGA) and alginate represent two different families of polymers widely used for microencapsulation application, even more, for vaccination purposes as particulate delivery/adjuvant systems. Combination of these polymers has been previously considered for tissue engineering and drug delivery, however there is currently no report regarding their combination for vaccine application. In the present work, a w/o/w solvent extraction technique was developed to prepare novel 1μm microparticles (MP) composed of PLGA and a small percentage of alginate (PLGA-alg MP).
View Article and Find Full Text PDFEmerging rules for subunit-based, multiantigenic, multistage chemically synthesized vaccines.
Acc Chem Res
March 2008
Fundacion Instituto de Inmunologia de Colombia, Bogota, Colombia, and Universidad Nacional de Colombia, Bogota, Colombia.
Seventeen million people die of transmittable diseases and 2/3 of the world's population suffer them annually. Malaria, tuberculosis, AIDS, hepatitis, and reemerging and new diseases are a great threat to humankind. A logical and rational approach for vaccine development is thus desperately needed.
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