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Accurate prediction of in vivo protein abundances by coupling constraint-based modelling and machine learning.
Metab Eng
November 2023
Bioinformatics, Institute of Biochemistry and Biology, University of Potsdam, Potsdam, 14476, Germany; Systems Biology and Mathematical Modelling, Max Planck Institute of Molecular Plant Physiology, Potsdam, 14476, Germany. Electronic address:
Quantification of how different environmental cues affect protein allocation can provide important insights for understanding cell physiology. While absolute quantification of proteins can be obtained by resource-intensive mass-spectrometry-based technologies, prediction of protein abundances offers another way to obtain insights into protein allocation. Here we present CAMEL, a framework that couples constraint-based modelling with machine learning to predict protein abundance for any environmental condition.
View Article and Find Full Text PDFReceptor kinase module targets PIN-dependent auxin transport during canalization.
Science
October 2020
Institute of Science and Technology (IST), 3400 Klosterneuburg, Austria.
Spontaneously arising channels that transport the phytohormone auxin provide positional cues for self-organizing aspects of plant development such as flexible vasculature regeneration or its patterning during leaf venation. The auxin canalization hypothesis proposes a feedback between auxin signaling and transport as the underlying mechanism, but molecular players await discovery. We identified part of the machinery that routes auxin transport.
View Article and Find Full Text PDFCigarette and smokeless tobacco company smartphone applications.
Tob Control
July 2019
Center for Tobacco Products, Food and Drug Administration (FDA), Silver Spring, Maryland, USA.
Purpose: Two previous studies indicate that prosmoking apps might encourage smoking behaviour via smoking cues. The current paper seeks to build on these studies and provide an updated overview of the characteristics of tobacco industry-sponsored apps.
Methods: In November 2017, we identified 19 unique top-selling cigarette brands, 20 smokeless tobacco brands, 30 e-cigarette brands and 43 cigar brands based on Nielsen sales from 2016 Nielsen Scantrack data and 2016 Kantar advertising data from the Kantar Media Stradegy database.
The Suprachiasmatic Nucleus of the Dromedary Camel (): Cytoarchitecture and Neurochemical Anatomy.
Front Neuroanat
November 2017
Neurobiology of Rhythms UPR 3212 CNRS, Institute for Cellular and Integrative Neurosciences, University of Strasbourg, Strasbourg, France.
In mammals, biological rhythms are driven by a master circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. Recently, we have demonstrated that in the camel, the daily cycle of environmental temperature is able to entrain the master clock. This raises several questions about the structure and function of the SCN in this species.
View Article and Find Full Text PDFFinite-element modelling of mechanobiological factors influencing sesamoid tissue morphology in the patellar tendon of an ostrich.
R Soc Open Sci
June 2017
Structure and Motion Laboratory, Department of Comparative Biomedical Sciences, The Royal Veterinary College, Hatfield, UK.
The appearance and shape of sesamoid bones within a tendon or ligament wrapping around a joint are understood to be influenced by both genetic and epigenetic factors. Ostriches () possess two sesamoid patellae (kneecaps), one of which (the distal patella) is unique to their lineage, making them a good model for investigating sesamoid tissue development and evolution. Here we used finite-element modelling to test the hypothesis that specific mechanical cues in the ostrich patellar tendon favour the formation of multiple patellae.
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