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Representativeness and adverse event reporting in late-phase clinical trials for rifampin-susceptible tuberculosis: a systematic review.
Lancet Infect Dis
November 2024
Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Provincial TB Services, British Columbia Centre for Disease Control, Vancouver, BC, Canada.
We did a systematic review and meta-analysis of trials of treatment for rifampicin-susceptible tuberculosis to evaluate the representativeness of participants compared with characteristics of the global population of people with tuberculosis, and the adequacy of adverse event reporting. We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews from Jan 1, 2000, to Dec 10, 2023, for trials that had greater than or equal to 50 participants per arm and had follow-up to at least treatment completion. Studies were excluded if they compared different formulations of standard drugs (eg, fixed-dose combination tablets); aimed to primarily enrol participants with isoniazid-resistant or rifampicin-resistant tuberculosis; evaluated treatment to prevent tuberculosis infection; tested dietary or vitamin supplementation; tested vaccines or other immune-based interventions; tested adherence support or system-related mechanisms; or enrolled participants with tuberculosis, but tuberculosis treatment itself was not randomised (ie, trials of the timing of antiretroviral therapy initiation).
View Article and Find Full Text PDFIsolated testicular tuberculosis: A case report.
Urol Case Rep
November 2024
Department of Urology A, Ibn Sina University Hospital, Rabat, Morocco.
Article Synopsis
- * A 41-year-old male with chronic left scrotal swelling was diagnosed with testicular tuberculosis after imaging and histopathology revealed caseating granulomas and acid-fast bacilli.
- * The patient had surgery to remove the affected testicle and received a standard four-drug TB treatment, but follow-up showed he had permanent fertility impairment due to azoospermia.
Bronchiectasis Development in a Male Patient With a History of Tuberculosis: A Case Report.
Cureus
August 2024
Clinical Embryology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Bronchiectasis is a chronic respiratory disease characterized by a syndrome of productive cough and recurrent respiratory infections due to permanent dilatation of the bronchi. In this case, we discuss a 32-year-old male patient with a history of tuberculosis (TB) from a rural area of Wardha, Maharashtra. The case discusses the diagnostic modalities confirming the diagnosis, sputum investigations, and imaging studies like chest X-ray, high-resolution computed tomography (HRCT), pulmonary function test (PFT), and bronchoscopy.
View Article and Find Full Text PDFModelling the preventive treatment under media impact on tuberculosis: A comparison in four regions of China.
Infect Dis Model
June 2024
National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
Preventive treatment for people with latent Tuberculosis infection (LTBI) has aroused our great interest. In this paper, we propose and analyze a novel mathematical model of TB considering preventive treatment with media impact. The basic reproduction number is defined by the next generation matrix method.
View Article and Find Full Text PDFPediatric sellar-suprasellar tuberculosis: A case report and review of the literature.
Surg Neurol Int
October 2023
Department of Neurosurgery, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University Morocco, Oujda, Morocco.
Background: Pediatric sellar-suprasellar tuberculosis is a rare form of tuberculosis that affects the pituitary gland and surrounding areas in the brain. It can be difficult to diagnose based on clinical and radiological signs alone, as they can be similar to other pituitary masses. A combination of biological, hormonal, and imaging examinations can aid in making an accurate diagnosis.
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