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In Situ-Forming, Adhesive, and Antioxidant Chitosan Hydrogels for Accelerated Wound Healing.
Biomacromolecules
January 2025
State Key Laboratory of Separation Membranes and Membrane Processes, School of Material Science and Engineering, Tiangong University, Tianjin 300387, China.
Antioxidant hydrogels that can provide a moist environment and scavenge reactive oxygen species have emerged as highly potential wound dressing materials. In situ-forming and good tissue adhesiveness will make them more desirable, as they can fill the irregular wound defect, stick to the wound, and offer intimate contact with the wound. Herein, a hydrogel dressing combining in situ-forming, good tissue adhesiveness, and excellent antioxidant capabilities was developed by simply conjugating dopamine onto carboxymethyl chitosan.
View Article and Find Full Text PDFPrimary duodenal T/histiocyte-rich large B-cell lymphoma complicated with obstructive jaundice: A case report and review of literature.
World J Gastrointest Surg
January 2025
Department of Gastroenterology and Hepatology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China.
Background: T/histiocyte-rich large B-cell lymphoma (T/HRBCL) is a highly aggressive subtype of diffuse large B-cell lymphoma characterized histologically by the presence of a few neoplastic large B cells amidst an abundant background of reactive T lymphocytes and/or histiocytes. T/HRBCL commonly affects the lymph nodes, followed by extranodal sites, such as the spleen, liver, and bone marrow, with rare occurrences in the gastrointestinal tract. Primary gastrointestinal T/HRBCL lacks specific clinical and endoscopic manifestations, and it is difficult to differentiate from inflammatory diseases, nodular lymphocyte predominant Hodgkin lymphoma, and other diseases on a histological basis, thereby hindering early diagnosis.
View Article and Find Full Text PDFSynergistically Enhanced Co-Adsorption of Reactant and Hydroxyl on Platinum-Modified Copper Oxide for High-Performance HMF Oxidation.
Adv Mater
January 2025
Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, 361005, P. R. China.
Electrochemical oxidation of biomass-derived 5-hydroxymethylfurfural (HMF) provides an environmentally friendly route for producing the sustainable polymer monomer 2,5-furandicarboxylic acid (FDCA). Thus, precisely adjusting the synergistic adsorption among key reactive species, such as HMF and OH, on the carefully designed catalyst surface is essential for achieving satisfactory catalytic performance for HMF oxidation to FDCA as it is closely related to the adsorption strength and configuration of the reaction substrates. This kind of regulation will ultimately facilitate the improvement of HMF oxidation performance.
View Article and Find Full Text PDFIntegrating Machine Learning and Pharmacophore Features for Enhanced Prediction of H1 Receptor Blockers.
Med Chem
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Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Introduction: Histamine Type I Receptor Antagonists (H1 blockers) are widely used to mitigate histamine-induced inflammation, particularly in allergic reactions. Histamine, a biogenic amine found in endothelial cells, vascular smooth muscle, bronchial smooth muscle, and the hypothalamus, is a key player in these responses. H1 blockers are essential in cough syrups and flu medications and are divided into two generations: first-generation H1 blockers, which are sedating and have numerous side effects, and second-generation blockers, which are non-sedating and generally less toxic but may still exhibit cross-reactivity with other receptors.
View Article and Find Full Text PDFRevealing Molecular Connections between Dissolved Organic Matter in Surface Water Sources and Their Cytotoxicity Influenced by Chlorination Disinfection.
Environ Sci Technol
January 2025
College of Environment and Ecology, Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing 400045, China.
Dissolved organic matter (DOM) is the primary precursor of disinfection products (DBPs) during chlorination. However, the compositional characteristics of DOM transformation during the chlorination process in different source waters and its relationship to cytotoxicity remain understudied. Here, we used high-resolution mass spectrometry to evaluate chlorination-induced molecular-level changes in DOM derived from different surface water sources.
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