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Specific immune response to and ability to control mycobacterial replication are not impaired in subjects with immune-mediated inflammatory disease and tuberculosis infection.
Front Immunol
January 2025
Translational Research Unit, National Institute for Infectious Diseases Lazzaro Spallanzani-IRCCS, Rome, Italy.
Background: Subjects with immune-mediated inflammatory diseases (IMID), such as rheumatoid arthritis, with tuberculosis infection (TBI), have a high probability of progressing to tuberculosis disease (TB). We aim to characterize the impact of IMID on the immune response to (Mtb) in patients with TBI and TB disease.
Methods: We enrolled TBI and TB patients with and without IMID.
Cardiovascular Implications of Non-steroidal Anti-inflammatory Drugs: A Comprehensive Review, with Emphasis on Patients with Rheumatoid Arthritis.
Eur Cardiol
December 2024
REMEDY Center for Treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital Oslo, Norway.
This review examines the cardiovascular risks associated with the use of non-steroidal anti-inflammatory drugs (NSAIDs), both traditional NSAIDs and cyclooxygenase-2 selective inhibitors (COXIBs). It describes the history of traditional NSAIDs and the development of COXIBs to explain why their cardiovascular side effects were unnoticed for many decades. Further, the review presents the mechanism of action of NSAIDs, to elucidate the possible underlying basis for why they are associated with an increased risk of cardiovascular disease.
View Article and Find Full Text PDFExploring the clinical profiles and management of juvenile dermatomyositis in Africa: a survey of African rheumatology care providers.
Pediatr Rheumatol Online J
January 2025
Aga Khan University Medical College East Africa, Nairobi, Kenya.
Background: There are limited studies of juvenile dermatomyositis (JDM) in low and middle-income countries (LMIC). Many demonstrate delays to care, high prevalence of severe manifestations, and high mortality. Given the disease-associated damage with JDM, understanding JDM in Africa further is critical.
View Article and Find Full Text PDFRisk factors for growth retardation in children with juvenile idiopathic arthritis: a case-control study.
BMC Musculoskelet Disord
January 2025
Department of Pediatric, Hebei Medical University Third Hospital, 139 Ziqiang Road, Shijiazhuang City, 050051, Hebei Province, China.
Objective: This study aimed to investigate the role of various factors contributing to growth retardation, including nutritional intake, disease duration, and treatment history, and further identify key risk factors that may influence growth outcomes in patients with juvenile idiopathic arthritis (JIA).
Methods: Clinical data from 155 JIA children who were treated at our hospital between January 2019 and December 2022 were analyzed. The children were divided into the growth retardation group (n = 40) and the non-growth retardation group (n = 115) based on the height Z-score < -2 SD or not.
High tibial osteotomy (HTO) is a widely used procedure for delaying knee arthroplasty, correcting alignment, and relieving symptoms in patients with knee osteoarthritis. Recently, proximal fibular osteotomy (PFO) has emerged as a less invasive and more cost-effective alternative. This study compares the outcomes of HTO and PFO to evaluate whether PFO can deliver results comparable to HTO in similar patient populations.
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