Studying RBC sedimentation in hematocrit capillaries filled with a variety of separation media (Sephacryl S-300, Ultrogel AcA22 and others) and spinned down for a short time we found some striking advantages in comparison to standard hemagglutination techniques. The scope of diagnostic procedures may be improved and broadened as far as anemias caused by autoantibodies and infections as well as hemolytic disease of the newborn--especially AB0-erythroblastosis--and pretransfusion testing are concerned.
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J Scleroderma Relat Disord
April 2024
Department of Pediatric Facial Plastic Surgery and Craniofacial Anomalies, Catholic Children's Hospital Wilhelmstift, Hamburg, Germany.
Objectives: The objective of this study was to evaluate the effect of autologous fat grafting in patients with juvenile localized scleroderma with facial involvement.
Methods: We retrospectively studied patients with juvenile localized scleroderma who were followed at the Hamburg Center for Pediatric and Adolescent Rheumatology at least 6 months post-operative follow-up and received at least one autologous fat transplantation for a facial lesion. Autologous fat grafting was conducted independent of disease-modifying treatment and/or disease activity.
J Scleroderma Relat Disord
November 2024
Division of Rheumatology, Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Arthritis Care Res (Hoboken)
November 2024
AbbVie Inc., North Chicago, Illinois.
Objective: This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular-course juvenile idiopathic arthritis (pcJIA).
Methods: In an open-label, phase 1 study (SELECT-YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight-based upadacitinib doses using a twice-daily oral solution or once-daily extended-release tablet based on their body weight and ability to swallow tablets. The study included a 7-day pharmacokinetic assessment, followed by a long-term efficacy and safety evaluation for up to 156 weeks, including an additional long-term safety cohort.
Syst Rev
October 2024
Ernst-Abbe-Hochschule Jena-University of Applied Science, Carl-Zeiß-Promenade 2, 07745 Jena, Germany.
Background: Physical therapy interventions play a crucial role in the daily care of patients recovering from severe stroke. However, the efficacy of these interventions and associated modalities, including duration, intensity, and frequency, have not been fully elucidated. In 2020, a systematic review reported the beneficial effects of physical therapy for patients with severe stroke but did not assess therapeutic modalities.
View Article and Find Full Text PDFPediatr Rheumatol Online J
October 2024
Programme Area Epidemiology and Health Services Research, Deutsches Rheuma-Forschungszentrum Berlin, a Leibniz Institute, Charitéplatz 1, 10117, Berlin, Germany.
Background: Regular physical activity (PA) has been proven to help prevent non-communicable diseases and is beneficial for disease management in chronically ill populations. Physical inactivity and recreational screen-based media (SBM) use are related to poor health outcomes and common among youth. This study aimed to (1) investigate PA levels and recreational SBM use of adolescents with JIA over time and (2) compare these behaviours with those of their peers.
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