The aim of this pilot study was to evaluate a new, non-invasive examination method using MRI for the quantification of the colonic transit time after oral administration of gadolinium-saline solution filled capsules. Healthy volunteers without previous or acute symptoms of gastrointestinal disorders were enrolled. After a 3-day diet for the standardization of gastrocolonic content the volunteers swallowed five Gd-DTPA/saline 0.9%-filled capsules. Seven different concentrations of Gd-DTPA/saline 0.9% solution between 1:0 and 0:1 were tested in a dilution series. Following ingestion of capsules, coronal Flash T1 and True Fisp sequences using a 1.5 Tesla system were obtained at 0 h, 3 h, 6 h, 12 h, 24 h, 36 h and 60 h. Sequences were analyzed by two independent experts for locating the capsules. Overall colonic transit time was separately analyzed for both genders. Fifteen healthy volunteers (7 females, 8 males; mean age 34+/-13 years) were enrolled. The phantom study provided the best contrast in both the T1-and T2-weighted sequences defining a ratio of 1:10 for Gd-DTPA/saline 0.9% solution. The mean transit time accounted for 41+/-9 h in women and for 31+/-10 h in men. MRI is an adequate method for the assessment of colonic transit time offering the advantages of no exposure to radiation, short examination time, possible dynamic evaluation of the transit and the practicability in terms of a future adoption to clinical routine.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00330-006-0414-z | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analyzing the channels of information dissemination: Investigating abrupt transitions in resource investment.
Chaos
January 2025
Department of Applied Mathematics, College of Applied Sciences, Kyung Hee University, Yongin 17104, Republic of Korea.
Investment in resources is essential for facilitating information dissemination in real-world contexts, and comprehending the influence of resource allocation on information dissemination is, thus, crucial for the efficacy of collaborative networks. Nonetheless, current studies on information dissemination frequently fail to clarify the complex interplay between information distribution and resources in network contexts. In this work, we establish a resource-based information dissemination model to identify the complex interplay by examining the propagation threshold and equilibriums.
View Article and Find Full Text PDFUnderstanding the Topology Freezing Temperature of Vitrimer-Like Materials through Complementary Structural and Rheological Analyses for Phase-Separated Network.
ACS Macro Lett
January 2025
Department of Life Science and Applied Chemistry, Graduated School of Engineering, Nagoya Institute of Technology, Gokiso-cho Showa-ku, Nagoya-city, Aichi 466-8555, Japan.
Vitrimers are sustainable cross-linked polymers characterized by an associative bond exchange mechanism within their network. A well-known feature of vitrimers is the Arrhenius dependence of the viscosity or relaxation time. Another important aspect is the existence of a topology-freezing temperature (), which represents a transition between the viscoelastic solid state and the malleable viscoelastic liquid state.
View Article and Find Full Text PDFBubble coalescence principle in saline water.
Proc Natl Acad Sci U S A
February 2025
School of Chemical Engineering and Technology, China University of Mining and Technology, Xuzhou 221116, China.
Bubbles present in saline water typically exhibit a prolonged lifetime, making them attractive for various engineering processes. Herein, we unveil a transition from delayed bubble coalescence to rapid bursting within about one millisecond in salty solutions. The key aspect in understanding this transition lies in the combined influences of surface deformation and ion surface excess instead of characterizing the ions alone.
View Article and Find Full Text PDFIntegrated analysis of marked and count data to characterize fine-scale stream fish movement.
Oecologia
January 2025
Department of Fish, Wildlife, and Conservation Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Immigration and emigration are key demographic processes of animal population dynamics. However, we have limited knowledge on how fine-scale movement varies over space and time. We developed a Bayesian integrated population model using individual mark-recapture and count data to characterize fine-scale movement of stream fish at 20-m resolution in a 740-m study area every two months for 28 months.
View Article and Find Full Text PDFListening to the Formation of Polymorphs in a Ball Mill.
Anal Chem
January 2025
ICGM, Univ. Montpellier, CNRS, ENSCM, 34000 Montpellier, France.
In this contribution, we apply our newly developed ball-milling platform, which combines Raman spectroscopy and thermal (IR) imaging, as well as acoustic and high-speed optical video recordings, to the synthesis and transformation of citric acid-isonicotinamide (1:2) cocrystal polymorphs in transparent PMMA jars. Particularly, we demonstrate how Raman, temperature, acoustic, and video data are complementary and enable detection and connection of chemical and physical events happening during ball-milling in a time-resolved manner. Importantly, we show that the formation of the three cocrystal polymorphs can be detected through acoustic analyses solely.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!