AI Article Synopsis
- Current vaccine candidate against Plasmodium vivax is the major merozoite surface protein-1 (PvMSP-1), focusing on its asexual blood stage.
- Vaccine trials have shown that PvMSP-1(19) can protect monkeys, and many people exposed to P. vivax develop antibodies to this protein.
- A new 3D model of the C-terminal 19kDa fragment of PvMSP-1 was created, revealing a binding pocket for protein interactions and serving as a framework for studying how antibodies connect with PvMSP-1(19).
Article Abstract
One current vaccine candidate against Plasmodium vivax targeting asexual blood stage is the major merozoite surface protein-1 of P. vivax (PvMSP-1). Vaccine trials with PvMSP-1(19) and PvMSP-1(33) have succeeded in protecting monkeys and a large proportion of individuals, naturally exposed to P. vivax transmission, develop specific antibodies to PvMSP-1(19). This study presents a model for the three-dimensional structure of the C-terminal 19kDa fragment of P. vivax MSP-1 determined by means of homology modeling and molecular dynamics refinement. The structure proved to be consistent with MSP-1(19) of known crystal or solution structures. The presence of a main binding pocket, well suited for protein-protein interactions, was determined by CASTp. Corrections reported to the sequence of PvMSP-1(19) Belem strain were also inspected. Our model is currently used as a basis to understand antibody interactions with PvMSP-1(19).
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| http://dx.doi.org/10.1016/j.bmc.2006.09.005 | DOI Listing |
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