Three series of acute experiments were carried out on dogs. In the first series pancreatic enzyme secretion (PES) was stimulated by intravenous injection of secretin and pancreozymin and selectively inhibited by intraduodenal injection of amylase; in the second series PES was induced by intraduodenal injection of acidified hydrolysin and nonselectively inhibited by intraduodenal injection of PES from the same dog; in the third series of experiments PES was stimulated by intraduodenal injection of hydrolysin, and selectively inhibited by intraduodenal injection of amylase. Activated carbon and gastric mucus were used as enterosorbents of enzymes. Their administration into the duodenum simultaneously with pancreatic amylase or pancreatic secretion eliminated or diminished their selective and nonselective inhibitory effects on pancreatic secretion of enzymes. A conclusion has been made that enterosorbents of duodenal enzymes reduce or eliminate the inhibitory action of pancreatic enzymes from the duodenal chyme on pancreatic secretion of enzymes.
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