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An MRI-Based Radiomics Model for Preoperative Prediction of Microvascular Invasion and Outcome in Intrahepatic Cholangiocarcinoma.
Eur J Radiol
December 2024
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Institute of Medical Imaging, Shanghai, China. Electronic address:
Purpose: Microvascular invasion (MVI) serves as a significant predictor of poor prognosis in intrahepatic cholangiocarcinoma (ICC). This study aims to establish a comprehensive model utilizing MR radiomics for preoperative MVI status stratification and outcome prediction in ICC patients.
Materials And Methods: A total of 249 ICC patients were randomly assigned to training and validation cohorts (174:75), along with a time-independent test cohort consisting of 47 ICC patients.
Targeted isolation of diketopiperazines from a deep-sea derived fungus with anti-neuroinflammatory effects.
Bioorg Chem
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China; Ningbo Institute of Marine Medicine, Peking University, Beijing 100191, PR China. Electronic address:
Prenylated indole diketopiperazines represent a diverse array of alkaloids with complex chemical scaffolds and with a wide range of biological activities. Aiming to discover bioactive metabolites with structural novelty, genomic annotation in association with the MS/MS-based molecular networking demonstrated a deep-sea derived fungus Aspergillus puulaauensis F77 containing a profile of diketopiperazines. Targeted separation of the cultured fungus led to the isolation of 19 undescribed austamide-type diketopiperazines namely versicoines A-S.
View Article and Find Full Text PDFEremophilane- and Acorane-Type Sesquiterpenes from the Deep-Sea Cold-Seep-Derived Fungus CS-280 Cultured in the Presence of Autoclaved QDIO-4.
Mar Drugs
December 2024
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Six new sesquiterpenes, including four eremophilane derivatives fureremophilanes A-D (-) and two acorane analogues furacoranes A and B ( and ), were characterized from the culture extract of the cold-seep derived fungus CS-280 co-cultured with autoclaved QDIO-4. All the six compounds were highly oxygenated especially and with infrequent epoxyethane and tetrahydrofuran ring systems. The structures of - were established on the basis of detailed interpretation of 1D and 2D NMR and MS data.
View Article and Find Full Text PDFCembranoid Diterpenes from South China Sea Soft Coral .
Mar Drugs
November 2024
Jiangsu Key Laboratory for Functional Substances of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Cembranoid diterpenes are characteristic compounds of soft corals with diverse structures and significant activities, making them an important source of drug lead compounds. In this paper, five new cembranoid diterpenes, meijicrassolins A-E (-), were isolated from the soft coral , along with five previously reported compounds (-). The structures and absolute configuration for new compounds - were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory/electronic circular dichroism (TDDFT/ECD) calculations.
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