A 19-month-old black girl had a radical nephrectomy for a Wilms' tumor that contained areas of epithelium indistinguishable from renal cell carcinoma. She was treated with chemotherapy but subsequently had pulmonary metastases develop and massive abdominal recurrence. The recurrent tumor was histologically renal cell carcinoma with no identifiable Wilms' tumor elements. The child died with recurrent and metastatic tumor 13 months after nephrectomy. Pathologic, immunoperoxidase, and flow cytometric studies of this unusual case are presented.
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http://dx.doi.org/10.1002/1097-0142(19910201)67:3<690::aid-cncr2820670327>3.0.co;2-f | DOI Listing |
Toxicology
March 2025
Department of Urology, Urology Research Institute, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China; Department of Urology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou 350212, China; Fujian Key Laboratory of Precision Medicine for Cancer, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China. Electronic address:
Bisphenol S (BPS) is widely used in the production of food containers and children's toys and is known to have endocrine-disrupting effects linked to various cancers; however, its role in renal cell carcinoma (RCC) development remains unclear. This study investigates the mechanisms by which BPS may promote RCC progression. The effects of BPS on proliferation and migration were evaluated in HK-2 and 786-O cells using CCK-8, scratch, and Transwell assays.
View Article and Find Full Text PDFComput Biol Chem
March 2025
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Institute of Urology, Capital Medical University, Beijing, China. Electronic address:
Background: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflammatory response during the IRI process. The objective of this study is to conduct an analysis of the developmental and differentiation characteristics of macrophages in IRI, identify distinct molecules subtypes of IRI, and establish robust predictive strategies for DGF and graft survival.
View Article and Find Full Text PDFBlood Adv
March 2025
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States.
Sickle cell trait (SCT) is present in subjects who possess a single copy of the bS-globin gene mutation. While most affected individuals are asymptomatic, SCT is a well-established risk factor for venous thrombosis and renal complications, including chronic and end-stage kidney disease. Following prolonged hypoxia, SCT red blood cells (RBCs) can undergo sickling, and hypoxia-mediated RBC sickling can be enhanced by cellular dehydration, hyperosmolarity and/or acidosis.
View Article and Find Full Text PDFInt Immunopharmacol
March 2025
College of Pharmacy, Chongqing Medical University, Chongqing 400016, China; Department of Clinical Pharmacy, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. Electronic address:
Diabetic nephropathy (DN), a leading cause of end-stage renal disease, presents significant challenges due to its complex pathophysiology and limited effective treatment options. Increasing evidence suggests that tubular injury is an early event preceding glomerular damage in DN. Wogonoside, a natural flavonoid derived from Scutellaria baicalensis, has not been previously reported for DN treatment.
View Article and Find Full Text PDFInt Immunopharmacol
March 2025
Department of Renal Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China. Electronic address:
NLRP3 inflammasome plays a key role in IgA Nephropathy (IgAN) pathogenesis. Thiolutin (THL) is an NLRP3 inflammasome inhibitor with anti-inflammatory effects, but its role in IgAN is unclear. This study aimed to evaluate the protective efficacy of THL in IgAN mice, alongside assessing its inhibitory mechanisms.
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