Background: Hereditary hemorrhagic telangiectasia (HHT) is a rare autosomal dominant condition. It is rarely seen in pregnancy and even more rarely has uterine manifestations.
Case: A 29-year-old primigravid woman with HHT was noted to have vascular manifestations of her disease in the lower uterus, distal rectum, pelvis, and bladder before pregnancy. Prior to delivery, a case conference was held, involving representatives of the departments of vascular surgery, hematology, radiology, anaesthesiology, maternal-fetal medicine, neonatology, and laboratory medicine, and other appropriate health professionals. A successful elective Caesarean section was performed at term, with a good outcome for both mother and child.
Conclusion: regnancies in women with HHT and associated uterine vascular manifestations have been rarely reported, and published information is minimal. We present a case of a successful operative delivery following careful multidisciplinary antepartum care.
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http://dx.doi.org/10.1016/S1701-2163(16)32224-1 | DOI Listing |
Reprod Biomed Online
October 2024
Department of Biomedicine Experimental Biology Unit, Faculty of Medicine of the University of Porto, Porto, Portugal.; Instituto de Investigação e Inovação em Saúde (i3S), Porto, Portugal.. Electronic address:
Research Question: Does metformin reverse endometriosis-associated infertility?
Design: Endometriosis was induced by transplanting uterus fragments from B6CBAF1 mice into recipients of the same strain. The mice were divided into groups: endometriosis (End, n = 24), sham-operated (Sham, n = 12), endometriosis with metformin (0.5mg/ml) orally administered for 3 months (EndMet, n = 21) and sham-operated metformin-treated (ShamMet, n = 16).
Int J Hyperthermia
December 2025
Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Objective: This study aimed to assess the effectiveness of conventional magnetic resonance imaging (MRI) combined with three-dimensional (3D) ultrasound for the preoperative prediction of nonperfused volume ratio (NPVR) in uterine fibroids after high-intensity focused ultrasound (HIFU) ablation.
Materials And Methods: In total, 178 patients who had undergone HIFU ablation therapy for uterine fibroids between July 2021 and August 2023 were enrolled. Baseline clinical, MRI, and 3D ultrasound parameters collected before and after HIFU ablation were analyzed.
Front Transplant
January 2025
Organ Donation Services, New England Donor Services, Waltham, MA, United States.
Vascularized composite allograft (VCA) transplantation represents a significant advancement in reconstructive surgery and offers hope to individuals who experienced congenital disorders or severe tissue injuries to restore physical appearance, function, and enhance quality of life. VCA recovery introduces complexities to conventional solid organ recovery, and there remain concerns regarding the potential impact of VCA recovery on non-VCA organs for transplant. The current retrospective study examines deceased donor characteristics and observed-to-expected (O/E) organ yield ratios for 51 VCA donors recovered in the US between July 4, 2014 and March 31, 2024, compared with a contemporary cohort of non-VCA donors recovered in 2023.
View Article and Find Full Text PDFFront Oncol
January 2025
Department of Vascular Intervention, Shengli Oilfield Central Hospital, Dongying, Shandong, China.
This report presents the case of a 68-year-old female patient with hepatocellular carcinoma (HCC) who experienced persistently elevated alpha-fetoprotein (AFP) levels following resection of the primary liver tumor. The patient had previously undergone transcatheter arterial chemoembolization (TACE) and liver tumor resection, but postoperative AFP levels continued to rise, suggesting the possibility of extrahepatic metastasis. PET-CT scans revealed an irregular soft tissue mass in the recto-uterine pouch, which was later confirmed as a HCC metastasis through needle biopsy.
View Article and Find Full Text PDFJ Toxicol Pathol
January 2025
Labcorp Early Development Laboratories, Inc., 3635 Concorde Parkway, Suite 100, Chantilly, VA, 20151, USA.
This technical report presents a collection of illustrative images and concise descriptions of non-neoplastic microscopic findings noted in transgenic CByB6F1-Tg(HRAS)2Jic (Tg.rasH2) mice from 26-week-carcinogenicity studies. A unique finding in the Tg.
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